protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.
Lentzen, "Cisplatin nephrotoxicity and protection by silibinin
," Nephrology Dialysis Transplantation, vol.
Anticancer effect of silibinin
on the xenograft model using MDA-MB-468 breast cancer cells.
Jung Ha Kim et al  showed that Silibinin
inhabits osteoclast differentiation mediated by TNF family members.
With that, they were able to discover that a promising lead compound Silibinin
was surprisingly very similar to a withdrawn drug called Plicamycin .
Milk thistle extracts, particularly silibinin
and silymarin, have numerous mechanisms that help prevent cancers from forming.
Another polyphenolic compound, the flavonolignan silibinin
, has been previously showed to bind PDIA3 with a dissociation constant within micromolar range .
Effects of the flavonoids, silibinin
, and catechin, on the motility of extended cooled caprine sperm.
is a potent sensitizer of UVA radiation-induced oxidative stress and apoptosis in human keratinocyte HaCaT cells.
Lee et al., "Silibinin
inhibits LPS-induced macrophage activation by blocking p38MAPK in RAW 264.7 cells," Biomolecules and Therapeutics, vol.
Effect and the probable mechanisms of silibinin
in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver.
regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.