silibinin


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silibinin

One of two major constituents of silymarin (silibinins A and B), the main extract of milk thistle (Silybum marianum seeds), which have hepatoprotective effects (e.g., against Amanita phalloides (deathcap mushroom) poisoning) and anti-cancer activity (in animal models) against prostate adenocarcinoma, breast carcinoma cells, cervical carcinoma cells, colon cancer and both small and non-small lung carcinomas. It may also be useful for cirrhosis and type-2 diabetes.
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Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.
Lentzen, "Cisplatin nephrotoxicity and protection by silibinin," Nephrology Dialysis Transplantation, vol.
Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells.
Jung Ha Kim et al [30] showed that Silibinin inhabits osteoclast differentiation mediated by TNF family members.
With that, they were able to discover that a promising lead compound Silibinin was surprisingly very similar to a withdrawn drug called Plicamycin [38].
Milk thistle extracts, particularly silibinin and silymarin, have numerous mechanisms that help prevent cancers from forming.
Another polyphenolic compound, the flavonolignan silibinin, has been previously showed to bind PDIA3 with a dissociation constant within micromolar range [47].
Effects of the flavonoids, silibinin, and catechin, on the motility of extended cooled caprine sperm.
Silibinin is a potent sensitizer of UVA radiation-induced oxidative stress and apoptosis in human keratinocyte HaCaT cells.
Lee et al., "Silibinin inhibits LPS-induced macrophage activation by blocking p38MAPK in RAW 264.7 cells," Biomolecules and Therapeutics, vol.
Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver.