silibinin


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silibinin

One of two major constituents of silymarin (silibinins A and B), the main extract of milk thistle (Silybum marianum seeds), which have hepatoprotective effects (e.g., against Amanita phalloides (deathcap mushroom) poisoning) and anti-cancer activity (in animal models) against prostate adenocarcinoma, breast carcinoma cells, cervical carcinoma cells, colon cancer and both small and non-small lung carcinomas. It may also be useful for cirrhosis and type-2 diabetes.
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Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.
Topical protection against skin aging and cancer
Lentzen, "Cisplatin nephrotoxicity and protection by silibinin," Nephrology Dialysis Transplantation, vol.
Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity
Anticancer effect of silibinin on the xenograft model using MDA-MB-468 breast cancer cells.
What is triple-negative breast cancer?
Jung Ha Kim et al [30] showed that Silibinin inhabits osteoclast differentiation mediated by TNF family members.
Evaluation of the effect of silymarin alone and in combination with calcium on bone formation, resorbtion and turn over in Ovariohysterectomized rat model
With that, they were able to discover that a promising lead compound Silibinin was surprisingly very similar to a withdrawn drug called Plicamycin [38].
Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective
Milk thistle extracts, particularly silibinin and silymarin, have numerous mechanisms that help prevent cancers from forming.
Healthy choices protect against colorectal cancer
Another polyphenolic compound, the flavonolignan silibinin, has been previously showed to bind PDIA3 with a dissociation constant within micromolar range [47].
Comparative Analysis of the Interaction between Different Flavonoids and PDIA3
Effects of the flavonoids, silibinin, and catechin, on the motility of extended cooled caprine sperm.
Ascorbic Acid Inclusion in Semen Extender Improves the Post-Thawed Semen Quality of Sahiwal Cattle (Bos indicus)
Silibinin is a potent sensitizer of UVA radiation-induced oxidative stress and apoptosis in human keratinocyte HaCaT cells.
Anti-aging Medicine: an anti-aging Approach to Skin Cancer Prevention
Lee et al., "Silibinin inhibits LPS-induced macrophage activation by blocking p38MAPK in RAW 264.7 cells," Biomolecules and Therapeutics, vol.
The regulatory role of activating transcription factor 2 in inflammation
Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver.
Mediterranean herb guards vital liver functions
Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.
Verticine, ebeiedine and suchengbeisine isolated from the bulbs of Fritillaria thunbergii Miq. inhibited the gene expression and production of MUC5AC mucin from human airway epithelial cells

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