silence

(redirected from silencing)
Also found in: Dictionary, Thesaurus, Legal, Idioms.

silence

 
absence of noise; a state of producing no detectable signs or symptoms.
electrical silence in electroencephalography and electromyography, absence of measurable electrical activity in tissue.

silence

(sī′ləns)
v.tr. si·lenced, si·lencing, si·lences
Genetics To interfere with the expression of (a gene or gene segment) so that its biological function is suppressed.

silence

1 absence of noise.
2 a state of producing no detectable signs or symptoms.
References in periodicals archive ?
The structure of p19 reveals that the protein selectively recognizes silencing siRNAs by measuring their length.
7, 1999 PROCEEDINGS OF THE NATIONAL ACADEMY oF SCIENCES, Willard's team reported that an unexpectedly large number of X chromosome genes, 34 of 224, resist silencing.
The issued claims not only cover minimising off-target gene expression silencing using short interfering RNA (siRNA) but also include specific claims directed to micro RNA (miRNA).
For example, a recent investigation based on silencing of 510 genes identified new cellular components that modulate the apoptotic response to tumor necrosis factor-related apoptosisinducing ligand (TRAIL) (Aza-Blanc et al.
Because every cell in a girl's body consults only one X, and picks which one at random, half her cells are ruled by the healthy silencing gene and half by the faulty copy.
In vivo systemic administration of ALN-PCS01 in mice was associated with dose-dependent and rapid silencing of the PCSK9 messenger RNA to more than 70 percent of control levels, with peak silencing effects observed as soon as 48 hours after dosing.
Several methods of gene expression analysis are available and there is still need for sensitive methods of detection of gene expression as a baseline and measurement after gene silencing.
Researchers using Drosophila found in 2000 that long-strand dsRNA was processed in cells into 21- to 23-nucleotide snippets of RNA, which then cleaved to precisely matching homologous mRNA sequences, degrading the mRNA and effectively silencing the corresponding gene by blocking its ability to encode for proteins.
Further, gene silencing of PCSK9 mRNA resulted in meaningful reductions in cholesterol levels, yielding in vivo evidence that pharmacologic targeting of PCSK9 may result in potential therapeutic benefit.
These siRNAs bind with other molecules to form the RNA-induced silencing complex, which allows the siRNAs to target specific messenger RNAs to block production of protein.
Several recent publications show successful gene silencing in human cells and experimental animals.