silencer motif

silencer motif

A 6–12 base-pair segment of DNA in immunoglobulin light-chain genes that binds to enhancer proteins, preventing upregulation or enhancer activity of non-B cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Screening of the DNA sequence flankings of rs7003908 (G>T) for enhancer motif, Exonic Splicing Enhancers (ESEs) and Intronic Splicing Enhancers (ISEs), and silencer motif, Exonic Splicing Silencers (ESSs) and Intronic Splicing Silencers (ISSs), by HSF 3 and SpliceAid 2 tools have shown almost same results.
However, SpliceAid 2 has not shown any change in the silencer motifs (Figures 6(a) and 6(a')), but HSF 3 displayed an ESS site broken for wild-type allele G and production of a new silencer motif site for mutant allele T which has potential alteration of splicing (Tables 4(e), 4(f), and 4(g)).
Bioinformatics analysis showed that although this SNP occurred in an acceptor splicing site and the transversion of allele G to allele T in XRCC7 6721 causes alterations such as increase in the score of the mutation and branch point sequences and can decrease, change, and remove some of the ESEs and also able to produce a new silencer motifs site which has potential alteration of splicing (Table 4 and Figure 6(a)), this variation cannot create new cryptic splice acceptor site, so this gene polymorphism has not severe modification on XRCC7 mRNA splicing.