signet-ring cell carcinoma


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sig·net-·ring cell car·ci·no·ma

a poorly differentiated adenocarcinoma composed of cells with a cytoplasmic droplet of mucus that compresses the nucleus to one side along the cell membrane; arises most frequently in the stomach, occasionally in the large bowel or elsewhere.
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Table 1: Cases of signet-ring cell carcinoma (SRCC) of the colon reported in the literature.
n Group A Shallow crypts 10 Small number of 3 crypt openings Curved crypt and long 2 intervening parts Short intervening parts 2 Group B Deep and straight crypts 4 Group C Signet-ring cell carcinoma in 4 the entire mucosal layers Very short intervening parts 1 Pseudostratified cancer cells 1 TABLE 3: Mean depth of crypts in groups A and B.
The extreme rarity of a primary colorectal signet-ring cell carcinoma metastatic to the tonsil reflects the fact that this particular histologic type of cancer occurs in only about 1% of all cases of colorectal carcinoma.
Furthermore, the histological appearance of primary signet-ring cell carcinoma of the urinary bladder is the same as that of other sites.
Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations.
[8] reported a 60-year-old case of signet-ring cell carcinoma of the urinary bladder successfully treated with radical cystectomy and creation of an ileal neobladder.
Primary signet-ring cell carcinoma of the lung: histochemical and immunohistochemical characterization.
Pure primary signet-ring cell carcinomas of the bladder are very rare and only a few case reports exist of a mixed urothelial/signet-ring cell variant.[sup.3,4] Saphir first described primary signet-ring cell carcinoma of the bladder in 1955, and less than 200 cases have been reported in the literature since then.[sup.5,6] There is a male preponderance and most patients present at an advanced stage.
Primary signet-ring cell carcinoma of the cervix is exceedingly rare (20,256-258) and it should always be a diagnosis of exclusion.
The differentiation of these 2 rare variants of melanoma is mainly of academic interest or for the sake of morphologic correctness because they generate the same major differential diagnosis, that is, signet-ring cell carcinoma in the gastric mucosal biopsy of an older patient, and the specific variant is unlikely to affect treatment decisions.
Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin.