(14) Morphologically, noncystic adenocarcinomas of the urachus are similar to primary adenocarcinomas of the urinary bladder and can demonstrate a range of histologic subtypes including (1) enterictype adenocarcinoma; (2) mucinous adenocarcinoma, with or without signet ring cells
; and (3) adenocarcinoma, not otherwise specified (see below for additional details).
Microscopy showed a focus comprising of signet ring cells
suggestive of gastric carcinoma.
Alcian Blue Stained Endoscopic Biopsy showing Signet Ring Cells
Immunohistochemical staining of the signet ring cells
demonstrated these cells to be negative for AE1/AE3, CD138, or Kreyberg staining while being positive for S-100 staining (Figures 1(e) and 1(f)); the immunoprofile was most consistent with atrophic adipocytes rather than signet ring cell
Young, "Primary ovarian mucinous tumors with signet ring cells
: Report of 3 cases with discussion of so-called primary krukenberg tumor," The American Journal of Surgical Pathology, vol.
Signet ring cells
are more frequently seen focally within otherwise high-grade prostate cancers and should be considered as part of the Gleason scoring.
Signet ring cells
and increased mitosis were also seen.
Histopathologic examination revealed that the mass was composed of pleomorphic cells that varied in shape, identified as cuboidal, columnar, and large round signet ring cells
. Neoplastic cells had areas of vacuolated cytoplasm with a small amount of mucous present.
Cytologic criteria were Nuclear morphology (Large nuclei, Anisonucleosis, Hyperchromatic nuclei, Vesicular nuclei, Chromatin clumping, Prominent nucleoli, Multiple nucleoli), and Cellular morphology (Comet cells, Signet ring cells
, Vacuolar cytoplasm, Granular cytoplasm, Apocrine cells, Ractive ductal cells, Squamous cells).
Mucinous and signet ring cells
were more often identified (p=0.041) in the gene product-deficient group (23.5% v.
"Signet ring cells
" were reported in pleural biopsy.
Myxoid liposarcomas are as common as the welldifferentiated type; they are composed of proliferating lipoblasts at varying stages of differentiation, signet ring cells
, a plexiform capillary pattern, and a myxoid matrix with nonsulfated glycosaminoglycans.