signet ring cell


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signet ring cell

A usually malignant cell containing copious clear cytoplasm that flattens a hyperchromatic nucleus to one side, having an appearance fancifully likened to a signet ring; CAs composed predominantly of SRCs often carry a worse prognosis; the 'classic'–and most common SRC occurs in the stomach, but is well described in CA of the breast, colon, gallbladder, lung, nasal cavity, prostate, thyroid–medullary carcinoma, urinary bladder, malignant SRCs may also be seen in non-epithelial malignancies–eg, mesothelioma, rhabdomyosarcoma, balloon cell melanoma, oligodendroglioma, myxoid angioblastomatosis, myxoid liposarcoma, lymphoma, and is a morphology typical of normal fat cells and oligodendrogliocytes.
References in periodicals archive ?
Overall, 64 patients who underwent gastric biopsy and were diagnosed with gastric adenocarcinoma and signet ring cell carcinoma between January 2011 and December 2013 were enrolled in the study along with 34 patients with benign gastric biopsy as the control group.
According to histology, the 3-year OS and PFS rates were 18% and 14% in the signet ring cell, whereas these were 47% and 38% in the mucinous type, and 55.4% and 51.3% in other adenocarcinomas, respectively (OS, p=0.482; PFS, p=0.283).
(12) reported a case of signet ring cell adenocarcinoma at the ileum 20 years after ileocystoplasty.
Mucinous Adenocarcinoma, Including Not Otherwise Specified, Intestinal, and Signet Ring Cell Types
An interesting situation was that lobular invasive cancers, which has gastric metastasis, contains signet ring shaped cells in pathologic examination and for this reason it was mistakenly thought that these patients might have a primary gastric cancer that is signet ring cell type gastric carcinomas (10).
The histopathology report showed the antral lesion came back as Signet ring cell carcinoma.
The retrospective study found that appendix cancer is comprised of five distinct subtypes- mucinous adenocarcinomas (46 percent), adenocarcinomas (30 percent), goblet cell carcinoids (12 percent), pseudomyxoma peritonei (7.7 percent) and signet ring cell carcinomas (5.2 percent).
Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the stomach.
Father-of-two David Scott, 41, was given the news that he has Stage 4 Signet Ring Cell cancer of the bladder in January.
Table 1 describes the findings from literature over the last two decades regarding cases of solitary juvenile polyp with adenomatous changes (one case without such changes, but with changes consistent with signet ring cell carcinoma in an adult patient).
Krukenberg tumour is an uncommon metastatic signet ring cell tumour of ovary that originates primarily in the stomach.1 They contribute only 30%-40% i.e.
Wang et al., "Early gastric cancer with signet ring cell histologic type: risk factors of lymph node metastasis and indications of endoscopic surgery," Surgery, vol.