signet ring cell


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signet ring cell

A usually malignant cell containing copious clear cytoplasm that flattens a hyperchromatic nucleus to one side, having an appearance fancifully likened to a signet ring; CAs composed predominantly of SRCs often carry a worse prognosis; the 'classic'–and most common SRC occurs in the stomach, but is well described in CA of the breast, colon, gallbladder, lung, nasal cavity, prostate, thyroid–medullary carcinoma, urinary bladder, malignant SRCs may also be seen in non-epithelial malignancies–eg, mesothelioma, rhabdomyosarcoma, balloon cell melanoma, oligodendroglioma, myxoid angioblastomatosis, myxoid liposarcoma, lymphoma, and is a morphology typical of normal fat cells and oligodendrogliocytes.
References in periodicals archive ?
Krukenberg tumour is an uncommon metastatic signet ring cell tumour of ovary that originates primarily in the stomach.
A proportion of signet ring cell adenocarcinomas found in the cervix are metastatic lesions, most commonly from a primary gastric carcinoma.
Doctors diagnosed the 43-year-old with signet ring cell adenocarcinoma, a highly malignant form of cancer almost immune to chemotherapy.
Induction of cytotoxic T lymphocytes from peripheral blood of human histocompatibility antigen (HLA)-A31(+) gastric cancer patients by in vitro stimulation with antigenic peptide of signet ring cell carcinoma.
Signet Ring Cell Lymphoma of the Small Bowel: A case report.
E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: Comparison with usual-type high-grade urothelial carcinoma.
The WHO classification of GC defined 222 (56%) cases as intestinal type adenocarcinoma, 68 (17%) cases as signet ring cell carcinoma (SRC), 62 (16%) cases as diffuse type and 42 (11%) cases as B cell non-Hodgkin lymphoma.
Only three cases of papillary adenocarcinoma were encountered and 7 cases of signet ring cell carcinoma.
Melissa Lacey, 33, has stage four signet ring cell appendix cancer - also known as pseudomyxoma peritonei - as well as bowel, ovarian and peritoneal cancer.
3%) the tumour was a mucinous or signet ring cell carcinoma.
Biopsy results indicated signet ring cell carcinoma.