signet ring cell


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signet ring cell

A usually malignant cell containing copious clear cytoplasm that flattens a hyperchromatic nucleus to one side, having an appearance fancifully likened to a signet ring; CAs composed predominantly of SRCs often carry a worse prognosis; the 'classic'–and most common SRC occurs in the stomach, but is well described in CA of the breast, colon, gallbladder, lung, nasal cavity, prostate, thyroid–medullary carcinoma, urinary bladder, malignant SRCs may also be seen in non-epithelial malignancies–eg, mesothelioma, rhabdomyosarcoma, balloon cell melanoma, oligodendroglioma, myxoid angioblastomatosis, myxoid liposarcoma, lymphoma, and is a morphology typical of normal fat cells and oligodendrogliocytes.
References in periodicals archive ?
Melissa Lacey, 33, has stage four signet ring cell appendix cancer - also known as pseudomyxoma peritonei - as well as bowel, ovarian and peritoneal cancer.
Primary signet ring cell carcinoma of the bladder: A report on 10 cases.
Signet ring cell lymphoma: a rare variant of follicular lymphoma.
In addition to enteric morphology, primary adenocarcinoma of the urinary bladder can exhibit other histologic growth patterns, including nonspecific (Figure 4, B), mucinous, signet ring cell (Figure 4, D), and clear cell types.
Biopsy results indicated signet ring cell carcinoma.
This edition has new and updated tables for immunochemistry, histologic appearance of viruses and fungi, and the optical properties of commonly seen noncellular material; the recommendations for American Joint Commission on Cancer classification and guidelines for the assessment of critical pathologic features; new tables for central nervous system tumors, lung carcinomas, fibroblastic/myofibroblastic lesions of the breast, signet ring cell carcinomas, metastatic carcinomas to the abdomen, and others; and evaluation of microsatellite instability in colon carcinomas.
Clinicopathological characteristics of signet ring cell carcinoma of the stomach.
Birnbaum ordered a gastrointestinal series and an abdominal ultrasound, which revealed a two centimeter mass in the patient's stomach Subsequent medical procedures confirmed the presence of infiltrative gastric adenoid carcinoma, signet ring cell type.
A biopsy was taken and the pathological examination showed a slightly differentiated adenocarcinoma that produced mucin and included signet ring cell.
Melissa, who has a husband, Carl, and son Evan, eight, has stage four signet ring cell appendix cancer - also known as pseudomyxoma peritonei - as well as bowel, ovarian and peritoneal cancer.
The patient was diagnosed as having a stage cT2bN0M1b prostatic signet ring cell adenocarcinoma and androgen deprivation therapy (ADT) was started at September 2011.
The cells were negative for cytokeratin (Figure 1, D), synaptophysin, chromogranin, CD56, smooth muscle actin, CD117, and HMB 45 markers, thus ruling out the possibilities of signet ring cell carcinoma, neuroendocrine neoplasm, smooth muscle tumor, gastrointestinal stromal tumor (GIST), and melanoma.