signal transduction


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signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
References in periodicals archive ?
Of particular significance for alternatives test development is the existence of a finite number of signal transduction pathways: less than 20 have been identified (Gerhart 1999).
For use in signal transduction courses for undergraduate and graduate students in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students, this text offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication.
Information from AxCell's signal transduction database should allow us to learn more about this protein and accelerate drug discovery efforts," said Dr.
It has been suggested that arsenic-induced MAPK signal transduction leads to activation of transcription factors such as activator protein-1 (AP-1) and nuclear factor-[kappa]B (NF[kappa]B), which in turn alters gene expression (Yang and Frenkel 2002).
AntexBiologics (Gaithersburg, MD; 301-590-0129) announced that the United States Patent and Trademark Office has allowed another patent on Antex's Helicobacter pylori vaccine produced using the company's Nutriment Signal Transduction platform technology.
Researchers in neurobiology, immunology, and related specialties provide a theoretical and practical foundation for scientists at any level who are interested in studying their role in signal transduction at the cellular level.
It is for readers with basic knowledge in biochemistry or molecular biology, and can be used as a reference for students and researchers and as a companion for a course on regulation and signal transduction.

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