signal transduction

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signal transduction

The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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In the experiments outlined below we utilize multiparameter phosphoflow cytometry to simultaneously quantify the activity of several different elements of the BCR signal transduction pathway on a single cell basis.

Elements of the b cell signalosome are differentially affected by mercury intoxication

The pathway builder portion of Protein Lounge allows users to create their own signal transduction pathways.

Protein Lounge

And the regulation of glucose metabolism, hormonal regulation and sugar signal are directly related to signal transduction (Mathieu et al., 2009; Kleinow et al., 2009).

The SnRK Protein Kinase Family and the Function of SnRK1 Protein Kinase

Protein kinase C (PKC) signal transduction system involved in larval metamorphosis of the barnacle, Balanus amphitrite.

Are G-protein-coupled receptors involved in mediating larval settlement and metamorphosis of coral planulae?

Since the establishment of the CoBRE in Signal Transduction, WVU faculty members have published approximately 300 scientific journal articles.

NIH awards $5.5 million to WVU for cancer research: five-year renewal recognizes Center of Biomedical Research Excellence

These proprietary lipid mediators, termed "Signal Transduction Modulators" or STMs, have significant pharmaceutical potential for treating regulatory dysfunctions underlying Alzheimer's, Parkinson's, Rosacea, Psoriasis and other diseases.

ADDF FUNDS SIGMUM BIOSCIENCES TO MOVE TO CLINIC

The gathering, which was organized by the American Association for Cancer Research (AACR) under the title "From the Laboratory to the Clinic", provided an overview of the most cutting-edge cancer research in various fields, including the tumor microenvironment, microRNAs, signal transduction, and novel therapeutic development.

Cancer research conference concluded

type II receptor to inhibit the signal transduction of human TGF-.beta.

Amgen Fremont obtains United States patent

By tracking single molecules inside cells, scientists can get a better understanding of events that occur within cells, such as signal transduction (the conversion, by a cell, of one signal or stimulus to another), crucial for the biomedical and pharmaceutical industries.

3-D tracking

Koretzky, MD, PhD, professor of pathology and laboratory medicine and director of the Signal Transduction Program at Penn's Abramson Family Cancer Research Institute, describes one way in which T cells may develop tolerance to host cells and proteins.

Study Sheds Light on Immune System

"Bio-Plex phosphoprotein assays built with CST antibody content provide the means for rigorous parallel analysis of signal transduction pathways," said CST Director of Business Development Christopher Bunder.

Bio-Rad expands agreement with CST

TNF-[alpha]-associated signal transduction has been well characterized.

Lead increases lipopolysaccharide-induced liver injury through tumor necrosis factor-[alpha] overexpression by monocytes/macrophages: role of protein kinase C and p42/44 mitogen-activated protein kinase