STAT1

(redirected from signal transducer and activator of transcription 1, 91kD)

STAT1

A gene on chromosome 2q32.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT1 protein product is activated by IFN-alpha, IFN-gamma, EGF, PDGF and IL6; it mediates the expression of various genes, which is important for cell viability in response to different cell stimuli and pathogens.
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