sideroblastic anaemia


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Related to sideroblastic anaemia: megaloblastic anaemia, Anaemia of chronic disease

sideroblastic anaemia

Rare disorders which may be hereditary or acquired and which features disordered iron metabolism. Clinically, they resemble other anaemias but treatment with iron makes things worse. Transfusion with red cell concentrates may be necessary. Vitamin B6 (pyridoxine) is sometimes effective.
References in periodicals archive ?
Differentials include haemoglobinopathies (thalassemias), lead or arsenic poisoning, unstable haemoglobins, severe infections, sideroblastic anaemia, megaloblastic anaemia and a rare inherited condition, pyrimidine 5' nucleotidase deficiency [14,22,42].
of Mean Hb MCV patients (g/dl) (fl) Myelodysplastic syndrome: 6 8.5 100 Refractory anaemia (RA 5 Sideroblastic anaemia 1 (RARS) No diagnostic features 24(*) 12.3 99.7 Dysplastic features: 19 12.8 99.2 Megaloblastic 8 Dyserythropoietic 11([dagger]) hypogranularity (*) Two patients were iron deficient.
Traditionally basophilic stippling is caused by denatured RNA fragments and associated with heavy metal poisoning, haemoglobinopathies, severe infections, sideroblastic anaemia and megaloblastic anaemia (6).
Sideroblastic anaemia includes a heterogeneous group of conditions characterized by decreased heme synthesis and mitochondrial iron overload.
Dimorphic anaemia can occur when iron deficiency anaemia responds to iron therapy, after the transfusion of normal blood to a patient with hypochromic anaemia, sideroblastic anaemia, refractory anaemia, macrocytic anaemia, post transfusion, unmasking of iron deficiency following treatment of megaloblastic anaemia, delayed transfusion reactions and dual deficiency of iron and either vitamin B12 or folic acid (4) which is the focus of our study.
Siderocytes had been noted on prior blood film examinations but it was not until this time that alcoholism was suggested as a cause, and that sideroblastic anaemia could be present in this patient.