sideroblastic anaemia


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Related to sideroblastic anaemia: megaloblastic anaemia, Anaemia of chronic disease

sideroblastic anaemia

Rare disorders which may be hereditary or acquired and which features disordered iron metabolism. Clinically, they resemble other anaemias but treatment with iron makes things worse. Transfusion with red cell concentrates may be necessary. Vitamin B6 (pyridoxine) is sometimes effective.
References in periodicals archive ?
Differentials include haemoglobinopathies (thalassemias), lead or arsenic poisoning, unstable haemoglobins, severe infections, sideroblastic anaemia, megaloblastic anaemia and a rare inherited condition, pyrimidine 5' nucleotidase deficiency [14,22,42].
Later, the researchers identified 10 additional causal mutations of this gene in other unexplained cases of congenital sideroblastic anaemia, and also showed a direct role of the gene in haemoglobin synthesis in zebra fish.
To understand the causes of sideroblastic anaemia, the pathway of haem synthesis is described in Figure 1.