sideroblast


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Related to sideroblast: Myelodysplastic syndrome, ferritin

sideroblast

 [sid´er-o-blast″]
an erythroblast containing ferritin granules in its cytoplasm. adj., adj sideroblas´tic.

sid·er·o·blast

(sid'ĕr-ō-blast'),
An erythroblast containing granules of ferritin stained by the Prussian blue reaction.
[sidero- + G. blastos, germ]

sideroblast

/sid·ero·blast/ (sid´er-o-blast″) a nucleated erythrocyte containing iron granules in its cytoplasm.sideroblas´tic
ringed sideroblast  an abnormal sideroblast with many iron granules in its mitochondria, found in a ring around the nucleus; seen in sideroblastic anemia.

sideroblast

[sid′ərōblast′]
Etymology: Gk, sideros, iron, blastos, germ
an iron-rich nucleated red blood cell in the bone marrow.

sideroblast

An erythroblast with iron granules (Pappenheimer bodies) seen in bone marrow by Prussian blue or Perl stains, which highlight iron.

sid·er·o·blast

(sid'ĕr-ō-blast)
An erythroblast containing granules of ferritin stained by the Prussian blue reaction.
[sidero- + G. blastos, germ]

sideroblast

A developing red blood cell with free iron granules in its CYTOPLASM. This is normal. Iron granules in the MITOCHONDRIA and forming a ring around the nucleus are characteristic of SIDEROBLASTIC ANAEMIA.

sideroblast

a nucleated erythrocyte containing iron granules in its cytoplasm.
References in periodicals archive ?
In 2007, a 60-year-old southern Italian man who presented with severe microcytic anemia, jaundice, hepatosplenomegaly, iron overload, ringed sideroblasts, and cirrhosis was reported (60).
Age, JAK2(V617F) and SF3B1 mutations are the main predicting factors for survival in refractory anaemia with ring sideroblasts and marked thrombocytosis.
Along with these, patients had either stainable iron in the bone marrow macrophages with reduced/absent siderocytes and sideroblasts and a raised ESR or CRP.
In iron depletion there will be few or no sideroblasts in reticulo endothelial system.
In general, the clinical course of hyperfibrotic MDS or MDS with myelofibrosis is rapidly progressive with short survival, except when myelofibrosis is associated with refractory anemia (RA) or refractory anemia with ring sideroblasts (BARS) subtypes [1,3,4].
London, May 9 (ANI): Scientists have found the gene, called SLC25A38, which causes congenital sideroblastic anaemia-a rare disease mainly characterized by the presence of ringed sideroblasts in the patients' bone marrow.
Megaloblastoid erythropoiesis with abnormal nuclear division (dyskinesis) and ringed sideroblasts are also present (Slides 5c, 5d, respectively).
Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.
DACOGEN is approved for treatment of patients with myelodysplastic syndromes (MDS), including previously treated and untreated, de novo and secondary MDS of all French-American-British (FAB) subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, chronic myelomonocytic leukemia), and Intermediate-1, Intermediate-2 and High-Risk International Prognostic Scoring System (IPSS) groups.
79,81,83) Furthermore, there is a link between mutations in SF3B1 and myelodysplasia with ring sideroblasts.