Sickling crisis | definition of sickling crisis by Medical dictionary
sickling crisis An acute episode in homozygous sickle cell disease in which a massive breakdown of red blood cells occurs with widespread severe pain from blockage of small blood vessels by sickled red cells. Some cases involve great enlargement of the liver or spleen and gross anaemia, others may affect the lungs with severe breathlessness and pleuritic pain, or the brain causing a stroke. Skilled and energetic management in hospital is mandatory for the sickling crisis.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive
Considering that fluted pumpkin gave much higher anti-sickling activities at a lower concentration, they said that its extract can be used as a prophylactic drug in offsetting sickling crisis
as well as be administered during a crisis to reduce the pain.
Herein, we report a case involving the coexistence of beta thalassemia minor, renal amyloidosis and FMF with the E148Q heterozygous mutation in a 46-year-old male patient with sickle cell anemia (SCA) whose abdominal pains had been attributed to sickling crisis
for almost 25 years.
2 patients who died following sickling crisis
The sickling crisis
in SCT women may occur in cases of extreme anaemia, dehydration, acidosis, vigorous exertion and at high altitude.
Preoperative exchange transfusion may be a safe alternate protocol to prevent a sickling crisis
"This can lead to these small blood vessels getting blocked which then stops the oxygen from getting through to where it is needed, a process known as sickling crisis