sickling


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Related to sickling: sickle cell anemia, sickling test, sickling crisis

sickling

 [sik´ling]
the development of sickle cells in the blood.
sickling test a method of demonstrationg hemoglobin S and the sickling phenomenon in erythrocytes, performed by reducing the oxygen concentration to which the erythrocytes are exposed.

sick·ling

(sik'ling),
Production of sickle-shaped erythrocytes in the circulation, as in sickle cell anemia.

sickling

/sick·ling/ (sik´ling) the development of sickle cells in the blood.

sickling

the development of sickle-shaped red blood cells, as in sickle cell anemia.

sick·ling

(sik'ling)
Production of sickle-shaped erythrocytes in the circulation, as in sickle cell anemia.

sickling

the development of sickle cells in the blood.

Patient discussion about sickling

Q. Please precribe for me the possible medicine (treatment) for sickle cells. Secondly, my boy lost hearing at 4 1- I need to know how sickle cells can be treated. 2- My boy just surprisingly lost his abillity to hear anything at the age of 4.

A. wow...you are going through some hard times...it's the hardest thing in the world seeing your children in pain. loosing his hearing could be caused by clots that were formed and destroyed the ear nerve. but it's unlikely it happened in both ears...so i would check it out. and about treatment- there are a variety of treatments, so i found a web site with them all. and even some that are still in research: http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_Treatments.html

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References in periodicals archive ?
Lastly, the authors state that our article advocated interpreting a negative sickling test as the patient being negative for the disease, with no further testing required.
We concluded that although the sickling test was not highly sensitive, it was more sensitive than solubility and the peripheral blood film method.
They hope to produce sicklier versions either by breeding these mice with others suffering from a related hemoglobin abnormality called thalassemia or by boosting the expression of the inserted sickling gene.
Because the gene for sickling is recessive, a child must inherit it from both parents in order to have the full-blown disease.
Another avenue of research seeks treatments to ease the symptoms of sickling.
Manning and Anthony Cerami of Rockefeller University in New York City discovered almost 20 years ago that cyanate salts could inhibit sickling in vitro by bonding to a site on the hemoglobin molecule, preventing the hemoglobin from taking on the rod configuration when deoxygenated.
The company has also shown, in two separate in vitro studies, that CPC-111 reduces the red blood cell sickling that causes the blood-starvation-induced tissue damage in sickle cell crisis.
The drug may prevent the red cell sickling, which causes the pain, and thus, shorten the crisis.
In pre-clinical studies, CPC-111 has been shown to prevent this sickling process.