Healthy red blood cell (RBC) half-life is one hundred and twenty days (120), while sickled erythrocyte
half-life is only seventeen (17) days.
The radiographical and pathological findings suggest that RMC probably originates in the calyceal epithelium in or near the renal papillae, which could be the result of chronic ischemic damage in the renal papillae epithelium by sickled erythrocytes
The aim of the study is to determine whether sickling also takes place in subjects without the genetic mutation for sickle cell trait and to check if artificially sickled erythrocytes
display the same resistance to Plasmodium spp parasites as do the genetically sickled ones.
published an important study that identified differences in the electrophoretic mobilities of normal and sickled erythrocytes (3).
Histologic examination found abundant sickled erythrocytes in small pulmonary vessels (online Technical Appendix Figure, panels C, D).
When sickled erythrocytes occlude the microvasculature, which of the following organs is at risk for damage due to tissue ischemia?
Sickled erythrocytes occlude the microvasculature resulting in tissue proliferation.
7-11) Other possibilities include increased intravascular shear forces, as a result of the adherence of sickled erythrocytes or injury by free fatty acids released from infarcted bone marrow.
In cases with thrombi in muscular pulmonary arteries, including those with large artery thrombi, sickled erythrocytes were frequently enmeshed in and adherent to the small arterial thrombi.
Structure of hemoglobin S fibers: optical determination of the molecular orientation in sickled erythrocytes
Nine patients had documented sickle cell trait, and 1 had hemoglobin S/C disease (although sickled erythrocytes
were seen in histologic sections in all cases except one).
Splenic dysfunction begins at about 6 months of age with congestion of the splenic red pulp by sickled erythrocytes