People with sickle-cell disease are also at high risk of other complications, especially stroke.
Acute chest syndrome--characterized by chest pain, fever, high blood pressure in the lungs, and a chest X ray showing clogged or collapsed lungs--is the most life-threatening complication of sickle-cell disease.
In just the third published case of nitric oxide use to treat sickle-cell disease, Paulette Mehta of the University of Florida College of Medicine in Gainesville and her colleagues reported similar success in the November 1999 CRITICAL CARE MEDICINE.
There are many possible explanations for nitric oxide's apparent benefits to people with sickle-cell disease.
The oxygen affinity of hemoglobin from three people without sickle-cell disease was unaffected.
He's starting a multicenter trial to test whether inhaled nitric oxide can reduce pain or illness in sickle-cell disease.
In mice with a disorder resembling sickle-cell disease, breathing nitric oxide seems to increase the survival of animals stressed by low oxygen, Head reported in the September 1999 ANESTHESIOLOGY.