Introducing an aldehyde reactive group on the antibody using sialyltransferase
(181) or formylglycine-generating enzyme (182),
Kwon et al., "Alpha 1,3-galactosyltransferase deficiency in pigs increases sialyltransferase
activities that potentially raise non-gal xenoantigenicity," Journal of Biomedicine and Biotechnology, vol.
The sialylation pattern of a cell is regulated by three group enzymes; Sia Synthase, Sialyltransferase
, and Sialydase or Neuraminidase.
Last, recent studies revealed that some non-HLA genes, such as sialyltransferase
ST8SIA2 , the complement regulator CSMD1 , and the integrin ITGA1 , may also be associated with cardiac manifestations of NLS., From maternal aspect, it was found that polymorphism in the interferon regulatory factor 5 gene was associated with asymptomatic mothers who had high-titer anti-Ro/SSA autoantibodies.,
Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase
in the hippocampi of neonatal rat pups.
Huang et al., "A novel sialyltransferase
inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways," Cancer Research, vol.
The 17 chapters explore simple and complex carbohydrates and glycoconjugates; methods of structural analysis of glycosaminoglycans, applications of these methods for identification of lysosomal storage diseases, and participation in the development of Lyme disease; the role of viral envelope protein glycosylation in the pathogenesis of influenza A virus; the application of lectin histochemistry in the diagnosis of lysosomal storage diseases; computational approaches for studying carbohydrate-lectin interactions in infection; the pathogenic effects of altered sialylation of specific glycoconjugates in genetic diseases; sialyltransferase
regulation of cancer-associated O-glycans; and the history of pectin study, chemistry, and medicinal uses of pectin.
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase
, CD75, on B cells.
In addition, the upregulation of the corresponding glycosyltransferases was also measured in the serum of ovarian cancer patients: ([alpha]1-3) fucosyltransferase , ([beta]1-4) galactosyltransferase , and ([alpha]2-6) sialyltransferase
Travassos, "Sialylglycoconjugates and sialyltransferase
activity in the fungus Cryptococcus neoformans," Glycoconjugate Journal, vol.
Furukawa et al., "Synthesis of disialyl Lewis a (Lea) structure in colon cancer cell lines by a sialyltransferase
, ST6GalNAc VI, responsible for the synthesis of a-series gangliosides," Journal of Biological Chemistry, vol.
After injury, regenerating hepatocytes have increased sialyltransferase
activity and synthesize hypersialylated proteins (e.g., fibrinogen B[beta] and [gamma] chains) with the increased negative charge, causing a decrease in polymerization rate.