Interactions between the bone matrix proteins osteopontin and bone sialoprotein
and the osteoclast integrin alpha v beta 3 potentiate bone resorption.
(BSP) is one of the most abundant noncollageneous and phosphorylated glycoproteins in human bone .
osteonectin), bone sialoprotein
is relatively restricted to bone.
Abbreviations Bat Batimastat BSA bovine serum albumin BSP bone sialoprotein
However, this protein divides into two proteins with diametrically opposed functions, dentin sialoprotein
(DSP) and dentin phosphoprotein (DPP).
Osteopontin, a phosphorylated sialoprotein
, is found in the bone extracellular matrix .
Grafted molecules recently reported are vitronectin, RGD, P15 peptide, bone sialoprotein
etc [35, 36, 37].
21) showed that in bone marrow cultures of rats treated with a high dose of dexamethasone, fetuin-A and TNF-[beta] suppressed bone alkaline phosphatase, osteopontin, type I collagen, and bone sialoprotein
(Solomon, 1999), clusterin (Mann et al.
Proteins such as podocalyxin, the major sialoprotein
of the cell membrane with a negative charge, appears to have a role in maintaining the SD structure.
paragraph]) bbp, gene encoding for bone sialoprotein
binding protein (adhesin).
Studies on bone sialoprotein
have suggested that one or both of the proteins glutamic acid-rich sequences are involved in promoting the nucleation of HAP (29), whereas the phosphate and carboxylate groups of osteopontin, possibly including the conserved sequence of contiguous aspartic acid residues, may be required for the proteins inhibitive effect on HAP formation (26).