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1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
An enzyme that catalyzes the hydrolysis of terminal acetylneuraminic residues from oligosaccharides, glycoproteins, or glycolipids; present on the surface antigen in myxoviruses; used in histochemistry to selectively remove sialomucins, as from bronchial mucous glands and the small intestine; a deficiency of this enzyme produces sialidosis.
Farlex Partner Medical Dictionary © Farlex 2012
An enzyme that cleaves terminal acylneuraminic residues from 2,3-, 2,6-, and 2,8-linkages in oligosaccharides, glycoproteins, or glycolipids; present as a surface antigen in myxoviruses. Used in histochemistry to selectively remove sialomucins, as from bronchial mucous glands and the small intestine. A deficiency of this enzyme will result in cherry-red-spot myoclonus syndrome (q.v.).
Medical Dictionary for the Health Professions and Nursing © Farlex 2012