sialidase


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sialidase

 [si-al´ĭ-dās]
1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.

si·al·i·dase

(sī-al'i-dās),
An enzyme that catalyzes the hydrolysis of terminal acetylneuraminic residues from oligosaccharides, glycoproteins, or glycolipids; present on the surface antigen in myxoviruses; used in histochemistry to selectively remove sialomucins, as from bronchial mucous glands and the small intestine; a deficiency of this enzyme produces sialidosis.
Synonym(s): neuraminidase

sialidase

an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal-recessive trait and is seen in sialidosis and galactosialidosis. See also neuraminidase.

si·al·i·dase

(sī-al'i-dās)
An enzyme that cleaves terminal acylneuraminic residues from 2,3-, 2,6-, and 2,8-linkages in oligosaccharides, glycoproteins, or glycolipids; present as a surface antigen in myxoviruses. Used in histochemistry to selectively remove sialomucins, as from bronchial mucous glands and the small intestine. A deficiency of this enzyme will result in cherry-red-spot myoclonus syndrome (q.v.).
References in periodicals archive ?
27) O-Acetylated Sia are relatively stable in intestine, since the action of intestinal sialidases is much reduced by Sia O-acetylation.
A recombinant sialidase fusion protein effectively inhibits human parainfluenza viral infection in vitro and in vivo," The Journal of Infectious Diseases, vol.
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
Lysosomal sialidase functions only when it is bound to another enzyme named cathepsin (Protective Protein Cathepsin A: PPCA).
But in the new study, researchers showed remarkable improvement on treating injured rat spinal cords with sialidase.
aches-based vaccines and vaccines built around cell wall-anchored sialidase of P aches are being studied.
1996, "Hybridization of 2659 Clostridium perfringens isolates with gene probes for seven toxins ([alpha], [beta], [tau], [theta], [mu] and enterotoxin) and for sialidase," Am.
Differential expression of sialylglycoconjugates and sialidase activity in distinct morphological stages of Fonsecaea pedrosoi.
Following completion of his PhD, Rich moved to Australia where he spent one year as an NSERC post-doctoral fellow in the laboratory of Mark von Itzstein, working on design and synthesis of new inhibitors of influenza virus sialidase.
4,21) Commercial tests that are available for diagnosis of BV include a proline aminopeptidase activity test card for detecting the presence of G vaginalis and a sialidase activity test.
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro.
Trypanosoma soma rangeli sialidase lacks trans-sialidase activity.