sialidase


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sialidase

 [si-al´ĭ-dās]
1. an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal recessive trait and is seen in sialidosis and galactosialidosis.
2. the enzyme with this activity specifically cleaving sialic acid–containing gangliosides; it is deficient in mucolipidosis IV. Called also neuraminidase.

si·al·i·dase

(sī-al'i-dās),
An enzyme that catalyzes the hydrolysis of terminal acetylneuraminic residues from oligosaccharides, glycoproteins, or glycolipids; present on the surface antigen in myxoviruses; used in histochemistry to selectively remove sialomucins, as from bronchial mucous glands and the small intestine; a deficiency of this enzyme produces sialidosis.
Synonym(s): neuraminidase

sialidase

an enzyme of the hydrolase class that catalyzes the cleavage of glucosidic linkages between a sialic acid residue and a hexose or hexosamine residue at the nonreducing terminal of oligosaccharides in glycoproteins, glycolipids, and proteoglycans. Deficiency of it is an autosomal-recessive trait and is seen in sialidosis and galactosialidosis. See also neuraminidase.

si·al·i·dase

(sī-al'i-dās)
An enzyme that cleaves terminal acylneuraminic residues from 2,3-, 2,6-, and 2,8-linkages in oligosaccharides, glycoproteins, or glycolipids; present as a surface antigen in myxoviruses. Used in histochemistry to selectively remove sialomucins, as from bronchial mucous glands and the small intestine. A deficiency of this enzyme will result in cherry-red-spot myoclonus syndrome (q.v.).
References in periodicals archive ?
Free and total sialic acid were tested in urine considering deficiency of sialidase enzyme located in the lyososmal membrane which presents with clinical findings due to sialic acid accumulation in the tissues and urine.
Sialidase has properties that are appealing from the human drug development point of view," said Dr.
From the results in Table 1, Euphorbia ammak, Tephrosia nubica and Adenium obesum potently reduced influenza virus titre, which were evaluated as viral sialidase activity.
Sialidase cuts the surface sugars thus making it impossible for the virus to attach.
An additional complicating factor is the occurrence of secondary causes of type II TIEF profiles, including hemolytic uremic syndrome (HUS) with the presence of pneumococcal sialidase in plasma (6), or severe liver pathology (7-9).
The war against influenza: discovery and development of sialidase inhibitors.
DAS181, a recombinant sialidase fusion protein, removes sialic acid residues from airway epithelium, thereby preventing both the initial step in PIV and IFV infection as well as the spread of existing infection.
To analyze the carbohydrate contents in human pro-ANP, pro-BNP, and pro-CNP, we carried out glycosidase digestion experiments using deglycosylation enzymes including PNGase F from Chryseobacterium meningosepticum, recombinant [alpha[-2(3,6,8,9) neuraminidase (also called sialidase A) from Arthrobacter ureafaciens, and recombinant O-glycosidase from Streptococcus pneumonia (Prozyme).
By contrast, the sialidase activity of the neuraminidase (NA) protein removes SA to liberate newly synthesized viruses from infected cells.
We obtained O-glycosidase (endo-[alpha]-N-acetylgalactosaminidase) from QA-Bio; sialidase A (N-acetylneuraminate glycohydrolase), [beta](1-4) galactosidase, and [beta]-N-acetylhexosaminidase from Prozyme; normal human EDTA-plasma from Innovative Research; Sepharose CL 4B from GE Healthcare; 96-well plates for immunoassays from Costar; and streptavidin-coated plates from Wallac-Perkin Elmer.
Amino acids responsible for the absolute sialidase activity of the influenza A virus neuraminidase: relationship to growth in the duck intestine.
The presentation was entitled "DAS181 (Fludase), a Sialidase, Decreases Airway Resistance by Modulating Muscarinic Receptor Signaling.