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Caption: In this cartoon, neuraminidase is depicted as a mouth which "bites" the bond between hemagglutinin (blue suction cup) and sialic acid (green rod).
Our new compounds are structurally more similar to sialic acid than Tamiflu.
Free and total sialic acid were tested in urine considering deficiency of sialidase enzyme located in the lyososmal membrane which presents with clinical findings due to sialic acid accumulation in the tissues and urine.
12) The prolongation of the TT by these fibrinogens strongly correlates with the increased sialic acid content.
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.
Diabaetes mellitus type II (DMII) often presents with increased serum sialic acid which is a strong predictor of cardiovascular mortality.
Terminal sialic acid residues are cleaved by viral neuraminidases, thereby inactivating receptors that are recognised by viral haemagglutinin.
The 24 contributions in this laboratory handbook present methods for overcoming the problems inherent in assays of water-insoluble biomolecules, assaying specific mammalian glycosyltransferases involved in the biosynthesis of N- and O-glycans of glycoproteins, and studying sialic acids, protein-bound carbohydrates of glycoproteins, extracellular glycoconjugates, and glycolipids.
These include iron, vitamins, some enzyme hormones, and particularly sialic acid, which are found as one of nature's richest sources in human milk oligosaccharides and across central nervous system structures.