Caption: In this cartoon, neuraminidase is depicted as a mouth which "bites" the bond between hemagglutinin (blue suction cup) and sialic
acid (green rod).
Our new compounds are structurally more similar to sialic
acid than Tamiflu.
Free and total sialic
acid were tested in urine considering deficiency of sialidase enzyme located in the lyososmal membrane which presents with clinical findings due to sialic
acid accumulation in the tissues and urine.
Hexose, hexosamine and sialic
acid are the basic components of the glycoproteins.
acid content was determined by the method of Warren (1959).
Achievements and challenges of sialic
12) The prolongation of the TT by these fibrinogens strongly correlates with the increased sialic
Functionally defective germline variants of sialic
acid acetylesterase in autoimmunity.
Diabaetes mellitus type II (DMII) often presents with increased serum sialic
acid which is a strong predictor of cardiovascular mortality.
acid residues are cleaved by viral neuraminidases, thereby inactivating receptors that are recognised by viral haemagglutinin.
The 24 contributions in this laboratory handbook present methods for overcoming the problems inherent in assays of water-insoluble biomolecules, assaying specific mammalian glycosyltransferases involved in the biosynthesis of N- and O-glycans of glycoproteins, and studying sialic
acids, protein-bound carbohydrates of glycoproteins, extracellular glycoconjugates, and glycolipids.
These include iron, vitamins, some enzyme hormones, and particularly sialic
acid, which are found as one of nature's richest sources in human milk oligosaccharides and across central nervous system structures.