siRNA


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siRNA

siRNA

short, interfering ribonucleic acid.

siRNA

abbrev. SHORT INTERFERING RNA
References in periodicals archive ?
Jorgen Wittendorff, newly appointed Head of Manufacturing of Silence Therapeutics, commented: 'Silence has an impressive portfolio of assets in the siRNA field and it is exciting to be involved in the development of products which have the potential to positively impact the lives of patients with serious diseases.
In rat studies, a head to head comparison of silencing activity of an siRNA and a previously reported antisense oligonucleotide targeting human superoxide dismutase 1 (hSOD1) was performed in a transgenic model expressing hSOD1.
The NOD mice (28-week-old) were randomly divided into four groups to undergo tail-vein injection (6 in each group): the negative control (phosphate buffered saline) group, the siRNA control (pGFP-V-RS vector) group, a-fodrin siRNA1 group, and a-fodrin siRNA2 group.
After transfection with siRNA against HER-3 and scrambling, viability of cells was investigated after 48, 72 and 96 hr by MTT assay.
Based on this background, in this study, we aimed to design and synthesize an effective nanocarrier for siRNA delivery.
Transfection with TNF[alpha] siRNA Decreases TNF[alpha] Levels, Phosphorylated [IRS-1.sup.Ser307] Levels, and Cleaved Caspase 3 Levels, as well as Increases Phosphorylated Insulin Receptor and Phosphorylated Akt Levels.
Although megalin has an extended half-life [25], other investigators have succeeded in providing serial daily or twice weekly administration of siRNA to reduce renal expression of other genes and proteins [11-13].
Pain treatment research has focused on using siRNA targeting NR2B to suppress the expression of NR as an effective way to treat chronic pain [3].
Downregulation of Cx43 by siRNA transfection inhibited the formation of GJs and ablated the recovery of chloride efflux as well as the increment in transepithelial resistance.