shuttle hypothesis

shuttle hypothesis

A posit that various molecules move from point A to B and back to effect their activities. For example, it had been proposed that TonB-coupled cytoplasmic membrane proton motive force to the active transport of large, scarce or important nutrients across the outer membrane, a theory that has now been discarded.
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According to Brooks (6), the cell-to-cell lactate shuttle hypothesis was introduced at an international congress in Belgium, in August 1984 (First International Congress of Comparative Physiology and Biochemistry).
It is interestingly that the initial lactate shuttle hypothesis (7) occurred before the discovery of the first MCTs proteins and their distribution in different tissues (17,18,45,57).
56), Brooks and Hashimoto (11) commented on several technical aspects of the study that may have led to not finding the expected results predicted by the intracellular lactate shuttle hypothesis.
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