shuttle hypothesis

shuttle hypothesis

A posit that various molecules move from point A to B and back to effect their activities. For example, it had been proposed that TonB-coupled cytoplasmic membrane proton motive force to the active transport of large, scarce or important nutrients across the outer membrane, a theory that has now been discarded.
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According to Brooks (6), the cell-to-cell lactate shuttle hypothesis was introduced at an international congress in Belgium, in August 1984 (First International Congress of Comparative Physiology and Biochemistry).
(56), Brooks and Hashimoto (11) commented on several technical aspects of the study that may have led to not finding the expected results predicted by the intracellular lactate shuttle hypothesis. Among them, vigorous homogenization may have caused the loss of mitochondrial components and the isolation of mitochondrial fragments (IMF) involved treatments using proteases, which may have resulted in the loss of mitochondrial MCT1 and LDH proteins during this process.
The confirmation of the intracellular shuttle hypothesis supports the role of mitochondria as the organelle responsible for the reconversion and oxidation of lactate.
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