short tandem repeat

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Related to short tandem repeat: Single nucleotide polymorphism, RFLP


A highly polymorphic segment of DNA composed of repetitive stretches of short sequences of 2–6 base pairs of DNA, which serve as genetic markers to track inheritance in families. Microsatellites include dinucleotides, trinucleotides and tetranucleotides, repeated in tandem arrays throughout a genome. The human genome has 50–100,000 microsatellite loci.

short tandem repeat (STR)

short repetitive DNA sequence. The repeat unit is generally 1–13 NUCLEOTIDES in length and the number of repeats varies in different individuals, usually from 5 to 20. The POLYMERASE CHAIN REACTION (PCR) can be used to determine the number of repeats at a LOCUS, by using PRIMERS that anneal either side of the STR, and analysing the size of the resulting PCR product after amplification. Useful for identification of individuals by DNA FINGERPRINTING.Also called microsatellite DNA
References in periodicals archive ?
Diversity of potential short tandem repeats in Mycobacterium leprae and application for molecular typing.
Compared with short tandem repeats or SNPs, segmental duplications are relatively less polymorphic in the human genome.
Rapid and high-throughput forensic short tandem repeat typing using a 96-lane microfabricated capillary array electrophoresis microdevice.
Many minisatellites, such as short tandem repeats (STRs), are highly polymorphic because of allelic variation in repeat copy numbers (2, 3).
Two main approaches used for monitoring chimerism are fluorescence in situ hybridization and PCR of short tandem repeats (STRs) expressing high degrees of polymorphism (1).
ECACC cell lines are authenticated using Short Tandem Repeat (STR) profiling and other proprietary techniques.
We examined whether other kidney donor-derived DNA sequences could be detected in the urine of transplant recipients, using PCR assays specific for highly polymorphic short tandem repeat (STR) loci, also termed microsatellite markers.
and Promega Corporation today announced that commercial deliveries of RapidHIT[TM] 200 Human Identification Systems will include Promega's nucleic acid purification and short tandem repeat (STR) amplification reagents.
Melissa May's paper, "Field-Deployable Rapid DNA Analysis: Fully Integrated, Fully Automated Generation of Short Tandem Repeat Profiles from Buccal Swabs.
Identification of repeat sequence heterogeneity at the polymorphic short tandem repeat locus HUMTH01[AATG]n and reassignment of alleles in population analysis using a locus-specific allelic ladder.
Microsatellite DNA or short tandem repeat (STR) [1] sequences are important in many types of genetic analysis, such as loss of heterozygosity testing, linkage analysis, gene mapping and discovery, paternity and forensic identity testing, evolutionary studies, and clinical diagnostics (1-10).
The test is based on a genetic variation known as short tandem repeat or "STR.

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