shikimic acid


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shikimic acid

parent chemical compound from which vanillin and salicylic acid are derived.
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Star Anise is one of the principal sources of Shikimic Acid which is at the centre of the controversy relating to the production of Tamiflu -- for Avian Flu -- by the pharmaceutical manufacturer, Hoffman LaRoche.
All flavonoid species are formed as a result of the biosynthesis of shikimic acid and acetate-malonate pathways together (3).
All plant phenolic compounds arise from a common intermediate, phenylalanine, or a close precursor, shikimic acid.
Two basic routes are widely recognized in the biosynthesis of phenolic compounds: first, the shikimic acid pathway and second, the malonic acid pathway.
They lead to the biosynthesis of simple to complex metabolites, utilizing the intermediates from the primary metabolites through specific pathways like shikimic acid pathway [9].
One of the most common classes of polyphenols are the C6-C1 structural group of hydroxybenzoic acid derivatives such as protocatechuic (1) and gallic acid (2) that are derived from the shikimic acid biosynthesis pathway (Figure 1).
The most abundant ones were gallic acid (7.18%), shikimic acid (5.07%), catechin (3.12%), 2-(diphenylphosphoryl)-4-nitrophenol (2.74%), and protocatechuic acid (1.13%).
Chlorogenic acid is a phenylpropanoid formed from the shikimic acid during aerobic respiration in plants.
They are mainly synthesized by polymalonate, shikimic acid and mevalonic acid pathways (Boustie and Grube, 2005).
INDIA is now capable of indigenously producing shikimic acid -- the most vital ingredient used to make Oseltamivir ( Tamiflu) -- an antiviral drug used in the treatment of H1N1 ( swine flu).
It was concluded that on changing levels of metabolites the heat treatment not only gives protection from chilling but also affects the levels of fructose-6-phosphate arabinose shikimic acid and valine producing chilling tolerance [16].
The current experiment was developed to study the effect of adding acetate (building unit), shikimic acid (precursor of cyclohexane moiety in Rap) and calcium superphosphate (CaP) on biosynthetic rate of Rap.