The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins
Of the several virulence factors, Shiga-like toxins
Stxl and Stx2 are considered to be the major virulence factors responsible for these clinical symptoms (Nataro and Kaper 1998).
Unfortunately, there is a potential for false-negative test results, particularly in stools that may contain low levels of Shiga-like toxins
This family of toxins was subsequently also called Shiga-like toxins
(SLT), and more recently Shiga toxins (Stx), because of the close relation to the Stx of Shigella dysenteriae type 1.
The patent covers the production and use of antibodies that detect Shiga-like toxins
(SLTs) or verotoxin (VT) producing strains of Escherichia coli 0157:H7 for use in the Company's VeroTest(TM) diagnostic product.
coli that are capable of producing Shiga-like toxins
1 and/or 2.
Enterohemorrhagic Escherichiae coli (EHEC) produce two potent cytotoxins called shiga-like toxins
Pseudomonas aeruginosa can cause false-positive identification of verotoxin (Shiga-like toxin
) production by a commercial enzyme immune assay system for the detection of Shiga-like toxins
Nasdaq: CARB, CARBU and CARBW) has developed a rapid and specific test to detect the Shiga-like toxins
(SLTs) of enterohemorrhagic E.
Effect of Shiga toxin and Shiga-like toxins
on eukaryotic cells.
These toxins are designated as verocytotoxins because of their toxic effects on cultured Vero cells or Shiga-like toxins
because of their similarity to the cytotoxin produced by Shigella dysentery type 1.
Non production of Shiga-like toxins
by Escherichia coli serogroup O26.