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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
This can happen for a number of reasons: heavy caseloads, frequent file transfers, lack of information and inexperience in spotting the severity indicators of a particular claim.
Disease severity in women with rheumatoid arthritis, measured early in pregnancy, is predictive of preterm delivery," noted Dr.
Speed was exposed as the other significant factor in determining severity of crashes, with severity escalating as speeds increase.
This may tell people they should ratchet up their loss severity a little bit in terms of calculating projections and payment timings and things like that on bonds," he said, adding that most industry professionals were expecting loss severities somewhere in the mid 40's.
Also, use of escitalopram significantly reduced hot flash severity compared with placebo, adjusted for race, site, and baseline severity.
That severity level is based on age along with the number and intensity of the diagnoses placed in the secondary diagnosis categories in the UB-04 Bill submitted to Medicare.
The EPR3 has made a distinction between classifying asthma severity and monitoring asthma control for three sub-groups of asthma patients based on age: 0 to 4 years, 5 to 11 years, and 12 years and older.
The Fuzzy rules, which are used for evaluation of severity indices of post-contingent quantities of line loadings are
An important motivation for the current research is that, with a single loss severity, the characterization of a partial coverage contract as involving a deductible or coinsurance is without content.
A total of 101 patients (60%) had both COPD and OSA, but there was no significant correlation between the severity of COPD and the severity of OSA based on the forced expiratory volume in 1 second (FE[V.
After 12 weeks of treatment, patients on 60 mg of duloxetine once or twice daily had improvements in average daily pain severity, night pain severity, and pain-related sleep interference, wrote Dr.
Compliance issues, as well as enhanced severity coding, will most likely require that more diagnoses appear on a bill just to sustain historic revenue streams.