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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
The airstrikes follow threats by President Uhuru Kenyatta that he would retaliate "in the severest way possible" against the Shebab militants for their attack on Thursday on a university in Kenya's northeastern town of Garissa in which nearly 150 died.
The severest punishments must be implemented, it's the only way to get through to these people" he said
We are optimistic that your and the government's efforts will help fast- track the matter so that the severest of punishment is meted out.
The Ministry confirmed its commitment to pursue the principle of transparency with all concerned bodies, as well as its commitment to implementation of the severest formal sanctions against anyone violating regulations and instructions.
CENTRE POMPIDOU * March 7-June 18 * Curated by Cecile Debray with Dorthe Aagesen and Rebecca Rabinow * Forget the rivalry between Picasso and Matisse: Matisse was, it appears, his own severest competitor.
He said that the government should take the business community in general and MCCI in particular on-board, as the gas shortage in Punjab is severest, while there is no shortage in other provinces.
SIRTE, October 10, 2011(TUR) - The city where Libyan leader Muammar Gadhafi was born, Sirte, experiences the severest moments of war in Libya.
Public Prosecutor Taher al-Kholy requested the severest punishment for Abu Zeid for deliberately attempting to endanger national security.
Over the past year, since 2010, there have been some of the severest cuts both in terms of the money local authorities have in engineering and education programmes and for local partnerships that run speed cameras.
At a time when we are bracing for the severest financial hardship in decades brought on by those grasping bankers, such revelation is likely to kill off what little trust we have left in humanity.
Al-Sadr continued stressed "I demand the severest penalties on those who perpetrated the crime according to the law .
As he continually spouts his twin global warming and pro-wind turbine mantras, the whole of Europe and North America is shivering in the grip of the severest winter for decades with heavy snowfalls and extremely low temperatures.