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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
We want the judge to give him a the severest sentence possible.
1840: The Birmingham and Gloucester Railway between Cheltenham and Bromsgrove was opened, a stretch that includes the Lickey incline, one of the severest gradients on a British main line.
It came days after President Uhuru Kenyatta's vowed "the severest possible" punishment for the attack.
President Uhuru Kenyatta had vowed to respond to the attack "in the severest way possible".
Summary: Airstrikes follow threats by President Kenyatta that he would retaliate 'in severest way possible' against Shebab for attack on Garissa university.
LAHORE -- The business community of the city Friday condemned in severest possible terms ugly terrorist attacks in Hayatabad,Peshawar.
I am demanding that in any cases where there is evidence of vessels dumping waste in our waters, the severest punishments must be afforded to the perpetrators and could result in hefty fines, loss of licences and even jail time.
Amritsar, Apr 11 ( ANI ): Former Punjab Chief Minister and Congress candidate from Amritsar Capt Amarinder Singh today condemned the rape remarks by Samajwadi Party chief Mulayam Singh Yadav, asserting, "rape is not a mistake, but a heineous crime that deserves severest punishment".
In the name of my colleagues in the Future Bloc we reject and deplore such criminal acts; judicial authorities must carry out extensive investigations and exact the severest punishment possible on criminals, Siniora concluded.
It is the severest alert since the Fukushima plant, located 230 km north of Tokyo, was damaged by a 9.
THE MOTHER of the 22- yearold Mumbai gang rape victim has demanded " severest punishment" to the five accused, saying that this would strike fear even into the " most sickminded" criminals.
The project plans to enhance food security and mechanisms for dealing with the severest affected people from the internally displaced persons (IDPs) and their host communities in Hajjah and the returnees in Abyan by maintaining and restoring and improving their productive assets.