severe

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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  
References in periodicals archive ?
However after 15d, weak shading (25%) had increased the soluble protein content in leaves, while all other severer shading (45%, 65% and 85%) caused a significant decrease in the soluble protein levels (Fig.
There is a higher risk of diabetes related complications in severer periodontitis.6
In the remaining 13 (28%) items there was difference of one level of recommended punishment except for recommended sanction for engaging in drug abuse, for which female students were 02 levels severer in recommended punishment.
3 CAPITAL LEASE Alternative to cash and retail Lease with characteristics of installment contractors, a purchase agreement, typically equipment is available for providing for a purchase option purchase at the end of the at nominal or below-market price lease for a nominal amount, no (also known as a Conditional penalties for severer operating Sales Lease).
But, when hole perpendicularity error is involved, element damage becomes severer and uneven, which can be seen by comparing Figures 11(b) and 11(c) with 11(a).
Without prejudice to any severer punishment stipulated under any other law, any person, who performs any of the following acts without prior written consent of the author or neighbouring right holder, shall be punished by detention for not less than three months and payment of fine not less than AED 50,000 and not more than AED 500,000:
"Our country's development faces more and greater difficulties, and severer challenges this year, so we must be prepared for a tough battle," Li said ahead of the country's annual meeting of parliament.
In the PD patients, the symptomatically milder side (MS) and severer side (SS) were determined according to the total scores obtained from the scores on the items of UPDRS3 for the right and left sides.
(tomato) or contexts (a, the); 2) hyphens and charades (resign/re-sign; markdown/mark down); 3) unrelated pairs (glower, severer); 4) proper nouns pronounced differently from same-root common nouns
"Stage 2 was high-frequency-deficient and occurred closest to Kathmandu, which was probably why ground shaking was less severer than expected for such a high-magnitude earthquake."
However, the punishment of the Hereafter is severer. Allah Almighty says: "Remember Me (by praying, glorifying), I will remember you, and be grateful to Me (for My countless favors on you) and never be ungrateful to Me." (Qur'an, 2:152) And, "Work you, O family of Dawud (David), with thanks!" But few of My slaves are grateful." (Qur'an, 34:13) He informs us that the grateful are few and most people do not thank Him.
Smallpox was not to be successfully treated until Edward Jenner (1749-1823) inductively pioneered the technique of vaccination at the end of the eighteenth century by examining (or as we might now say "interrogating") the folk-lore that milkmaids were pretty: in fact, their faces were likely to be much less disfigured than those of their unfortunate contemporaries because not only had they contracted the much less devastating "cowpox" but (crucially) this gave them natural immunity to the severer disease.