severe

(redirected from severely)
Also found in: Dictionary, Thesaurus, Legal, Wikipedia.

severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  

severe

a clinical qualifier that describes a disease that is so severe that it dominates all other activities.

severe combined immune deficiency disease (SCID) (syndrome)
References in periodicals archive ?
As a disabled Vietnam veteran, I know that these brave, severely wounded soldiers' adjustment back to normal life will be challenging.
A BMI of 40 or more, 280 pounds for a 5-foot-10 person, is considered severely or morbidly obese.
The control mice remained severely disabled, he says, with tremors and muscle weakness making walking difficult and in some cases impossible.
For the more extreme things women do to their hair, such as chemical treatments and flat-ironing, Dove Advanced Care Therapy For More Severely Damaged Hair helps repair dryness and brittleness and uses a patented Silicone Technology(TM) that seeks out the damaged area of hair, where women need it most.
8 per cent of children in the London borough - around one in 13 - were classed as severely obese in 2016/17.
Last year's SBFP targeted 532,752 severely wasted and 627,403 wasted students in public schools nationwide.
5 million New Yorkers now living in a crowded or severely crowded home.
The World Health Organization says it is too soon to say whether there could be an outbreak of a SARS-like killer respiratory disease after health officials in Britain announced they detected a related virus in a severely ill patient from the Middle East.
Of these, 105 eggs were from severely obese women, defined as having a body mass index (BMI) between 35.
ALMOST two out of three severely obese children under the age of 12 have at least one risk factor for heart disease such as high blood pressure or high blood sugar, researchers have said.
The concession entitles people who are registered blind or severely sight impaired to purchase their annual licence at the reduced fee of pounds 72.
There are no more severely wounded people," the source pledged.

Full browser ?