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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  
References in periodicals archive ?
Severely demented patients had the most trouble with the facial analogue scale because their ability to recognize faces was impaired, said Dr.
Sandwell had the highest rate of severely obese Year 6 pupils, at 6.1 per cent, a total of 256 pupils in 2016/17, followed by Birmingham at six per cent, a total of 861 pupils.
In 2017, about 60,000 youngsters were obese by the time they left primary school, with 22,000 labelled severely obese.
The first data of its kind for 2016/17, supplied by the National Child Measurement Programme (NCMP), shows that 4.1% of 10 and 11 year-olds across the country are classed as severely obese.
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When it came to severely and very severely obese, both men and women had low income and/or wealth.
New Delhi [India], Dec 18 ( ANI ): A minor was severely injured in a road accident in the wee hours of Monday.
This new report shows that the problem of crowding is stubbornly increasing, with nearly 1.5 million New Yorkers now living in a crowded or severely crowded home.
Xiao presented a cross-sectional baseline report on 242 severely obese adolescents with a median body mass index of 50.5 kg/[m.sup.2].
PEOPLE in Huddersfield who are severely sightimpaired, or living with someone who is, have been urged to claim their 50% reduction in the cost of their annual TV Licence.
PNN On Monday, 30th July, media spokesperson of the Popular Committee Against Settlement in Beit Ummar, Mohammad Ayad Awad, said that the Israeli forces arrested a young Palestinian suffers from a mental illness after they severely beat him in front of his parents.

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