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severe

adjective Referring to the intensity (severity) of a specific event, as in mild, moderate or severe.

The term “severe” is not synonymous with serious, as an event may be of acute distress but relatively minor medical significance (e.g., a severe headache). Seriousness serves as a guide for defining regulatory reporting obligations.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

proteinuria

Nephrology The excretion of excessive (> 5 mg/dL) protein in the urine; normally, about 150 mg/day of protein is lost in the urine,13 is albumin,13 is Tamm-Horsfall glycoprotein; the rest is divided among actively secreted proteins–eg, retinol binding proteins, β2-microglobulin, Ig light chains and lysozyme; in absence of disease, large proteins are retained due to their size, while the smaller proteins are actively resorbed; proteinuria is most often caused by kidney disease, due to glomerular defects, and defective renal tubular resorption, and most often detected by screening with reagent strip–dipstick. See Functional proteinuria, Overflow proteinuria.
Proteinuria, severity
Severe ≥ 1.0 g/dL, due to glomerulonephritis, nephrotic syndrome, lupus nephritis, amyloidosis
Moderate ≥ 0.2 g/dL, ≤ 1.0 g/dL, due to CHF, drugs, acute infections, myeloma, chemical toxins
Mild 0.05-0.2 g/dL, due to polycystic kidneys, pyelonephritis, renal tubular defects
Proteinuria, patterns
Glomerular pattern Due to a loss of fixed negative charge on the glomerular capillary wall, allowing albumin and other large (≥ 68 kD) molecules to leak into Bowman's space–eg, in glomerulonephritis and nephrotic syndrome Lab ↓ albumin, antithrombin, transferrin, prealbumin, α1-acid glycoprotein, α1-antitrypsin
Hemodynamic pattern Due to rheostatic changes in the body, causing a loss of 20 to 68 kD molecules, seen in transient proteinuria, CHF, fever, seizures, excess exercise.
Overflow pattern Due to tissue/cell destruction that overwhelms renal capacity to excrete certain proteins–eg, Bence-Jones proteinuria and myoglobinuria
Tubular pattern Due to renal tubular dysfunction with loss of normally filtered low molecular weight (≤ 40 kD) molecules Lab ↓ β2-microglobulin and lysozyme–eg, Fanconi syndrome, Wilson's disease, interstitial nephritis, antibiotic-induced injury and heavy metal intoxication  
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Prior to this, partial limb reattachments have been performed at KNH, but never a successful full reattachment of a completely severed limb.
The severed lots will be serviced by municipal water and septic systems.
A ship dragging its anchor off the coast of the Kenyan port city of Mombasa severed a crucial Internet and phone link for the region Saturday, crippling electronic communications from Zimbabwe to Djibouti, according to a public-private consortium that owns the undersea cable.
This change may have impacted the economic feasibility of constructing a road over the severed parcel over the same period of time.
"I would hate anyone else to find themselves in my position simply because a medic missed something as relatively straightforward as a severed tendon."
Hours later, doctors at the hospital's plastic surgery department managed to attach the severed hand back to the arm after a six- hour operation.
The estranged husband of a mother-of-two Geeta Aulakh, who was found with horrific injuries including a severed hand, has been charged with her murder, police said.
When it's time to reunite the severed limb with its owner, doctors quickly connect the ends of the broken bones.
Essex fire service said the man's severed limbs had been recovered in the hope surgeons would be able to save them.
MYSTERY surrounded the silencing of bells at an ancient church yesterday after the bell ropes were severed.
FITCHBURG - The right arm of a 41-year-old woman was severed and her right leg was partially severed yesterday by a freight train near the depot on Main Street, according to the Fire Department and a police sergeant with the Massachusetts Bay Transportation Authority.
Rocca also stated that the severed cables were discovered at the beginning of the working day on Friday.

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