severe cutaneous adverse reaction


Also found in: Acronyms.

severe cutaneous adverse reaction

,

SCAR.

Any of several potentially life-threatening rashes resulting from exposure to a drug. Included in this group are acute generalized exanthematous pustulosis, drug reactions with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
References in periodicals archive ?
The hazard rate for severe cutaneous adverse reactions with allopurinol was 21.3 after adjusting for age.
Song et al., "Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans," Epilepsy Research, vol.
Table 1: Treatments for severe cutaneous adverse reactions (SCARs).
Aw, "Severe cutaneous adverse reactions in a local hospital setting: a 5-year retrospective study," International Journal of Dermatology, vol.
Ng et al., "Association between HLA-B* 58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong," British Journal of Dermatology, vol.
AEDs have been recognized as being among the most common medications associated with severe cutaneous adverse reactions, with relative risks reported to be 15%, 11%, 13%, and less than 5% for phenobarbital, CBZ, PHT, and oxcarbazepine, respectively.
HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis.
These severe cutaneous adverse reactions (SCAR) are characterized by epidermal necrosis, extensive detachment of the epidermis, erosions of the mucous membranes and severe constitutional symptoms.
The term severe cutaneous adverse reactions (SCARs) was coined to, predominantly, include Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms syndrome (DRESS) and acute generalized exanthematous pustulosis (AGEP).
Subsequently, inclusion criteria for HSS/DRESS were defined in RegiSCAR, a research group investigating severe cutaneous adverse reactions (SCAR), and a scoring system for classifying DRESS cases was established (Table 1(b)) [7].
Chang, Adverse Drug Reaction Research Group in Korea et al., "Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans," Epilepsy Research, vol.
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