sevelamer


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Related to sevelamer: lanthanum, Cinacalcet

sevelamer

 [sĕ-vel´ah-mer]
a phosphate binder used as the hydrochloride salt to reduce serum phosphorus concentrations in hyperphosphatemia associated with end-stage renal disease; administered orally.

sevelamer

A phosphate chelator used to reduce phosphorus in patients with end-stage renal disease and in chronic renal failure patients not requiring dialysis. It also reduces uric acid levels, and may be of use in patients with hyperuricaemia, uric acid nephrolithiasis and gout.

Adverse effects
Blood pressure lability (hypo- or hypertension), nausea, vomiting, dyspepsia, diarrhoea, constipation.

sevelamer

Renagel® Nephrology A chelator used to ↓ phosphorus in Pts with ESRD and in chronic renal failure Pts not requiring dialysis. See Chelation, End-stage renal disease.
References in periodicals archive ?
Second-quarter Renvela[R] /Renagel[R] (sevelamer) sales decreased 57.3% to [euro]100 million, due to generic competition in the U.S.
The dose of sevelamer and cinacalcet was modified according to the levels of serum calcium, phosphate, and parathyroid hormone.
(BSE: 500124) (NYSE: RDY) has launched Sevelamer Carbonate for Oral Suspension, in 0.8 g and 2.4 g packets, a therapeutic equivalent generic version of Renvela (sevelamer carbonate) for Oral Suspension, in the US market following approved by the US Food and Drug Administration (USFDA), the company said.
Specifically, the electrolyte imbalances were addressed, continuing with the use of noncalcium-containing phosphate binders, such as sevelamer; as well stopping treatment with acenocoumarol that it may contribute to disease's progression.
A phosphate binder, sevelamer helps to prevent low levels of calcium in the body (hypocalcemia) caused by elevated phosphorus.
Product Monograph PrRENVELA[R] sevelamer carbonate tablets.
There was evidence that non-CBB like sevelamer was cost-effective in two European countries; the value of this information is limited in the local setting due to differences in health systems and cost structures [17-19].
Her home medications included amiodarone, aromasin, aspirin, carvedilol, diltiazem, pantoprazole, sevelamer hydrochloride, cinacalcet, and albuterol.
Indian multinational pharmaceutical and biotech company Cipla (NSE: CIPLA) confirmed on Friday that its subsidiary InvaGen Pharmaceuticals Inc has received final approval from the US Food and Drug Administration (FDA) for Sevelamer Carbonate tablets, 800 mg.
Sevelamer (Renvela and Renagel, Sanofi SA, Paris, France) is the newest member of the resin family.
Sevelamer has pleiotropic effects on lipid profiles, fibroblast growth factor 23, inflammation, uremic toxins, oxidative stress, and fetuin A and improves endothelial dysfunction.
Two recent meta-analyses found a reduced risk of all-cause mortality with the non-calcium-based binders sevelamer or lanthanum as compared to calcium-based binders.