revealed the presence of sesterterpenes [6, 7], sesquiterpenes [8, 9], macrolides , indole and AY- carboline alkaloids [11-13].
Emara, Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta, J.
Kashman, "New sesterterpenes from Madagascan Lendenfeldia sponges," Tetrahedron, vol.
The heteronemin, a marine sesterterpene isolated from the sponge Hyrtios sp., inhibits NF-[kappa]B activation and activates both initiator caspase-8 and caspase-9, which are implicated in the extrinsic and intrinsic apoptotic pathway, respectively, in chronic myelogenous leukemia cells .
Examples include salinamides A and B, which are depsipeptides produced by a marine streptomycete ; the cyclomarins, which are cyclic peptides that are also produced by a marine streptomycete ; lobophorins A and B, which are complex macrolides isolated from marine actinomycete cultures ; mangicols A and B, which are sesterterpenes isolated from the marine fungus Fusarium heterosporum ; and mycoepoxidiene, which is produced by a fungus in the genus Diaporthe .
Fenical, "Mangicols: structures and biosynthesis of a new class of sesterterpene polyols from a marine fungus of the genus Fusarium," The Journal of Organic Chemistry, vol.