serum protein

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Related to serum protein: serum albumin, albumin, Serum protein electrophoresis

serum protein

Etymology: L, serum, whey; Gk, proteios, first rank
any of the proteins in blood serum. See also serum globulin.

serum protein

Any protein in the blood serum. The two main fractions are albumin and the globulins. Serum protein forms weak acids mixed with alkali salts; this increases the buffer effects of the blood but to a lesser extent than does cellular protein.
See also: protein


any large organic compound made from one or more polypeptides, which are chains of amino acids joined in a genetically determined order by peptide linkages between the carboxyl group of one amino acid and the amino group of the next. They contain carbon, hydrogen, oxygen and nitrogen and usually sulfur, occasionally phosphorus.
Proteins form a large and essential part of the body mass, comprising especially cell membranes, connective tissue, muscles, enzymes, hormones, blood proteins. To maintain this mass the diet must contain a high proportion of protein, especially in growing animals and those recovering from debilitating diseases.

protein A
a surface protein of Staphylococus aureus which binds to the Fc region of some IgG molecules. Fluorochrome-labeled protein A is used in an indirect immunofluorescence test for detecting bound immunoglobulins.
authentic protein
a recombinant protein with all its naturally occurring properties.
available protein
the portion of dietary protein that can be used by the animal.
protein binding
a property of many drugs which limits their distribution and availability in the blood, as well as affecting elimination from the body.
protein bumps
see bumps.
protein C
a circulating vitamin K-dependent protein with anticoagulant effects. Promotes fibrinolysis.
calories derived from proteins in the diet.
protein calorie malnutrition
inadequate protein in the diet leads to impaired cell-mediated immunity, delayed wound healing and loss of lean body mass.
protein-calorie ratio
the number of calories provided from protein sources, compared with the total caloric intake; an indication of the level of protein intake.
carrier protein
one which, when coupled to a hapten, renders it capable of eliciting an immune response.
complete protein
one containing the essential amino acids in the proportion required in the diet.
protein concentrates
feeds containing a high concentration of protein, e.g. legume grains and forages, meat meal, fish meal, oil cakes, milling residues including bran, shorts, middlings, brewer's grains.
conjugated p's
those in which the protein molecule is united with nonprotein molecules or prosthetic groups, e.g. glycoproteins, lipoproteins and metalloproteins.
protein-creatinine ratio
in urine is valuable in correcting for variation in urine contents due to variable dilutions.
crude protein
the total nitrogen content of a feed multiplied by 6.25. Includes several obvious errors but is still a close approximation of the protein content.
dietary protein
is usually the most expensive part of the diet, except for animals at pasture, and the constituent most likely to be deficient. An excess of protein in the diet in ruminants can cause a sharp rise in alkalinity, due to the release of ammonia, of the ruminal contents causing ruminal atony and indigestion.
digestible protein
the crude protein ingested less the protein excreted in the feces. The estimation requires a digestibility trial involving animals.
protein equivalent
said of a feed. The total nitrogen content expressed as protein if it were all in that form. That is the percentage nitrogen in the feed multiplied by the average percentage of nitrogen in plant protein (6.25%).
protein excretion t
one that uses 51Cr-labeled protein which measures protein excretion in the feces in cases of protein-losing enteropathy.
protein-fibrinogen ratio
see plasma protein:fibrinogen ratio.
fibrous p's
characterized by shape, structure and low water solubility; they have a structural role. Examples are collagen, keratin and tropomyosin.
fusion protein
in recombinant DNA technology when a foreign gene is inserted into a plasmid vector to interrupt a gene, such as lacZ, the mRNA transcript of the recombinant plasmid contains the lacZ Shine-Dalgarno sequence and codons for the 3′ end of the lacZ gene protein followed by the codons of the foreign gene; the protein expressed is a fusion protein containing a few N-terminal lacZ amino acids and the contiguous foreign protein.
protein hydrolysates
pharmaceutical preparations used in the treatment of severe, acute protein loss. Available for use orally or parenterally. They are partly digested proteins and contain a mixture of polypeptides, amino acids and other breakdown products.
protein microarray
an ordered set of small samples of proteins immobilized on a microscope slide or other solid surface that is used to determine protein-protein interactions.
myeloma protein
see multiple myeloma.
protein nutritional deficiency
causes lack of muscle development, and slow growth rate and maturation. In adults there is a low milk production and poor weight gain. In severe states tissue and blood levels fall, hypoproteinemic edema may occur, and a degree of immunosuppression could be expected.
partial protein
one having a ratio of essential amino acids different from that of the average body protein.
peripheral protein
any protein located in the membrane but not essential to the reconstitution of that protein.
plasma p's
all the proteins present in the blood plasma, including the immunoglobulins. See plasma protein.
polyhedrin matrix protein
a protein that comprises the major component of occlusion bodies produced by nuclear polyhedrosis virus and cytoplasmic polyhedrosis virus; the strong polyhedrin promoter is utilized in the expression of recombinant proteins in baculovirus expression systems.
rec A protein
an enzyme that binds to DNA and plays an important role in genetic recombination.
protein S
a circulating vitamin K-dependent protein with anticoagulant effects.
serum protein
proteins in the blood serum, including immunoglobulins, albumin, complement, coagulation factors and enzymes.
protein shock
anaphylaxis occurring after the intravenous injection of protein.
in times of energy deficiency the animal body may raid protein stores for glucogenic amino acids, thus depleting body stores of proteins. Substances such as acetic acid which can fill the energy deficiency and avoid the protein loss are known as protein-sparing.
protein supplements
feeds which contain more than 20% protein.
urine protein
viral protein
proteins encoded by the viral genome.


pl. sera, serums [L.] the clear portion of any animal or plant fluid that remains after the solid elements have been separated out. The term usually refers to blood serum, the clear, straw-colored, liquid portion of the plasma that does not contain fibrinogen or blood cells, and remains fluid after clotting of blood.
Blood serum from animals whose bodies have built up antibodies is called antiserum or immune serum. Inoculation with such an antiserum provides temporary, or passive, immunity against the disease.

serum albumin mastitis test
a high concentration of serum albumin in milk indicates the presence of mastitis in the quarter.
antilymphocyte serum
serum breaks
in classical swine fever (hog cholera) vaccination when a serum-simultaneous vaccination program is not effective and it is assumed that the hyperimmune serum was ineffective.
serum clot time
see prothrombin consumption test.
serum enzymes
enzymes of individual tissues are released into the blood when the tissue is damaged or when there is much activity in it. The levels are used as a measure of activity or injury.
resistant to the effects of serum.
serum glutamic-oxaloacetic transaminase (SGOT)
serum glutamic-pyruvic transaminase (SGPT)
immune serum
serum from an immunized animal, containing specific antibody or antibodies.
serum osmolality
a measure of the number of dissolved particles per unit of water in serum. See also serum osmolality.
pooled serum
the mixed serum from a number of animals.
serum protein
see serum protein.
serum sickness
a group of immediate or antibody-mediated hypersensitivity reactions (also referred to as type III hypersensitivities) that includes Arthus reaction, serum sickness and immune complex diseases. The pathogenesis involves formation of bulky antibody-antigen complexes in the walls of small blood vessels; the complexes fix complement and cause necrosis and thrombus formation. There is infiltration of polymorphonuclear cells from which lysosomal enzymes are released.
serum-simultaneous immunization
an outdated method of vaccination, most popular at one time in the vaccination of pigs against classical swine fever (hog cholera). Live virus and antiserum to the virus were injected into the patient simultaneously; breakdowns in the system were frequent, leading to severe outbreaks of the target disease.
serum thymic factor
a humoral factor enhancing T lymphocyte responsiveness.
References in periodicals archive ?
Serum protein electrophoresis was performed on blood samples collected from 105 falcons that were submitted to the Dubai Falcon Hospital (Dubai, United Arab Emirates) between 2003 and 2006.
We noticed that there were significant linear correlation between age and pleural fluid glucose level, pleural fluid protein and serum protein, pleural fluid LDH and serum LDH and pleural fluid glucose and pleural fluid cholesterol.
Using microfiltration, dairy scientists can filter liquid milk to remove serum proteins prior to using the milk for cheesemaking.
In contrast, age, sex, blood pressure, fever, abdominal or loin pain, myalgia, headaches, fatigue, bleeding signs, hemoglobin, prothrombin time, activated partial thromboplastin time, C-reactive protein, sodium, potassium, ALT, serum protein, and proteinuria were not associated with serum creatinine >620 [micro]mol/L (Table 1).
We undertook the present study to document the effect of RPPHS on among-manufacturer coefficients of variation (AMCVs) in the CAP Surveys for the major serum proteins.
Affilin([R]) therapeutics are derived from of the natural serum protein Ubiquitin, a protein with ubiquitous distribution pattern in the human body.
2] Nonstandard abbreviations: SPEP, serum protein electrophoresis pattern; IFE, immunofixation electrophoresis.
Milan Panic, Chairman and CEO of MP Biomedicals, said, "We feel that this world class protein separation platform provides the manufacturing organization resources needed for MP Biomedicals to more fully serve customer demands for quality, low-risk serum protein materials collected and produced in the pristine environment of New Zealand.
Some references suggest using a ratio of fluid to serum protein to differentiate transudate from exudate.
Laboratory tests demonstrated anemia of chronic disease diagnosed by a hematocrit of 25% associated with a low reticulocyte production index, high serum ferritin, and an elevated erythrocyte sedimentation rate (91 mm/hr), with polyclonal hypergammaglobulinemia and hypoalbuminemia on serum protein electrophoresis.
utility patent application filed on December 7, 2006, involving 12 blood serum protein biomarkers.
As part of her evaluation, a serum protein electrophoresis test was ordered (Fig.