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A protein fraction of serum composed chiefly of antibodies.
Etymology: L, serum, whey, globulus, small globe
one of a group of proteins in blood serum with antibody qualities. The various types of serum globulins, designated alpha, beta, and gamma, have different specific properties.
serum globulinOne of the soluble protein fractions of blood serum. Most of the serum globulins are ANTIBODIES (immunoglobulins).
a general term for proteins that are insoluble in water or highly concentrated salt solutions but soluble in moderately concentrated salt solutions. All plasma proteins except albumin and prealbumin are globulins. The plasma globulins can be separated into five fractions by serum protein electrophoresis (SPE). In order of decreasing electrophoretic mobility these fractions are the alpha1, alpha2, beta1 and beta2 globulins, and the gamma globulins.
The globulins include carrier proteins, which transport specific substances; acute phase reactants, which are involved in the inflammatory process; clotting factors; complement components; and immunoglobulins. Examples are transferrin, a beta1 globulin that transports iron, and alpha1-antitrypsin, an acute phase reactant that inhibits serum proteases. The gamma globulin fraction is almost entirely composed of immunoglobulins.
a substance present in plasma, but not in serum, that functions in the formation of intrinsic and extrinsic thromboplastin; called also clotting factor V.
antihemophilic globulin (AHG)
clotting factor VIII.
antilymphocyte globulin (ALG)
a substance used as an immunosuppressive agent in organ transplantation, usually in combination with immunosuppressive drugs; it is the gamma globulin fraction of antilymphocyte serum.
a sterile solution containing antibodies normally present in blood, derived from donor animals, sometimes after hyperimmunization with certain microorganisms; used for passive immunization against some infectious diseases and in the treatment of gamma globulin deficiency.
the fraction of proteins precipitated from blood serum by half saturation with ammonium sulfate; the principal groups include the α-, β- and γ-globulins.