GHR

(redirected from serum binding protein)

GHR

A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.

Molecular pathology
Defects in GHR cause Laron type dwarfism.
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For a euthyroid subject with serum binding protein concentrations within the appropriate reference intervals, ~0.
Any valid assay must encompass the whole physiologic range of serum binding protein concentrations.
4] values may correlate with one or more of the serum binding protein concentrations.
If the FTI is acting as a hybrid assay, imperfectly correcting for the natural variation in serum binding protein concentrations in the panel, then it will correlate more closely with total [T.
4] is used, the same hormone is being used to assess unoccupied sites, with the same affinities as the hormone already occupying the serum binding protein sites.
4] results no longer significantly correlate with serum binding protein concentrations, even albumin (64-66).
3], as well as finally preventing the interference of any other serum binding protein in the assay (64-66).
4] values, even when the serum binding protein concentrations (especially transthyretin and albumin) were also severely decreased.
From the known equilibrium constants for the three serum binding proteins, thyroxine-binding globulin (TBG), transthyretin, and albumin (5, 6), a maximum of 5% of the protein-bound [T.
Such experiments, in which (unlike the case with equilibrium dialysis or ultrafiltration) the serum binding proteins, their [T.
These studies also revealed that serum binding proteins can be protective of DNA antimitotic activity, but because fetuses and newborns have lower concentrations of serum proteins than adults, they could be more vulnerable.
soluble receptors, heterophilic antibodies, serum binding proteins, hemoglobin, and lipids) in sera that can interfere with antibody-based immunoassays (18).