sertindole


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sertindole

A phenylindole antipsychotic drug used to treat SCHIZOPHRENIA. A brand name is Serdolect. This is one of the few drugs with the distinction of having been withdrawn and then reintroduced (with stated precautions).
References in periodicals archive ?
Asenapine, blonanserin, iloperidone, lurasidone, and sertindole: Distinctive clinical characteristics of 5 novel atypical antipsychotics.
In addition, some second-generation antipsychotics, including asenapine, clozapine, olanzapine and sertindole, are relatively potent 5-HT receptor antagonists and others, including amisulpride, asenapine, clozapine, amisulpride, lurasidone and risperidone, have high affinity for 5-HT receptors.
First generation antipsychotics with an increased risk of QTc prolonging include tioridazina (the highest risk), pimozide, droperidole, mesoridazine and haloperidole with intravenous administration (total cumulative dose > 2 mg) and from the second generation sertindole, amisulpride and ziprasidone.
Sertindole was never marketed in the US [6]; mesoridazine was marketed in the US but with a warning regarding dose-related QTc prolongation and associated risk of torsade de pointes [6].
De Bartolomeis, "Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole," Psychopharmacology, vol.
Tanyeri, "Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice," Pharmacology Biochemistry & Behavior, vol.
Effects of olanzap ine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice.
In the literature, oculogyric crisis cases related to clozapine, aripiprazole, amisulpride, ziprasidone, and sertindole have been reported.
Antipsychotic medication Drug substance Atypical Amisulpride Aripiprazole Clozapine Olanzapine Paliperidone Quetiapine Risperidone Sertindole Zotepine Typical Perphenazine Benperidol Chlorpromazine Chlorprothixene Droperidol Flupentixol Fluphenazine Haloperidol Levomepromazine Loxapine Oxypertine Pericyazine Pimozide Promazine Remoxipride Sulpiride Thioridazine Trifluoperazine Trifluperidol Zuclopenthixol GPRD were recorded and collected independently from each other.
Eberhard, and W Haverkamp, "QTc interval prolongation and antipsychotic drug treatments: focus on sertindole," International Journal of Neuropsychopharmacology, vol.
Tantawy, "Stability-indicating chromatographic methods for the determination of sertindole," Journal of Chromatographic Science, vol.