serpin


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serpin

 [ser´pin]
any of a superfamily of inhibitors of serine endopeptidase (serine proteinase), found in plasma and tissues; all are similarly structured single-chain glycoproteins although each one acts specifically on particular endopeptidases. Among their targets are serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha1-antitrypsin, antithrombin III, α2-antiplasmin, C1 inhibitor, and plasminogen activator inhibitor 1 (PAI-1). Called also serine protease or proteinase inhibitor.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

serpin

(ser′pĭn) [ ser(ine) + p(roteinase) + in(hibitor)]
A serine protease inhibitor.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Our test studied 5 single nucleotide polymorphisms (SNP) with the highest individual odds ratio for venous thrombosis (25) (Factor V Leiden, PT G20210A, A1 blood group, 1 SNP in the Fibrinogen - gene, 1 in the Factor XI gene) as well as some rare genetic variants linked to the thrombosis risk, with stronger effects in the carriers, such as the SERPIN C1 gene (26), the R67X in SERPIN A10 gene (27), or Ser219Gly in the PROCR gene (28).
In the literature, there is some evidence of a relationship between serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades, activated by an inflammatory cytokine storm, which can induce systemic inflammation with a loss of normal serine protease inhibitor (serpin) function.
* The report provides a snapshot of the global therapeutic landscape for Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1)
In addition, TAAs may belong to a variety of protein families that are structurally and functionally distinct such as SERPINs [6].
Besides its role in the fibrinolytic system, PAI-1 or serpin E1 plays a role in many human vascular disorders, and recent studies revealed that another serpin, serpin E2 also known as protease nexin-1 (PN-1) phylogenetically relative to PAI-1, is produced by most vascular and blood cells [35].
Further studies performed by introducing the cowpox virus serpin and caspase-8 inhibitor CrmA in the cells, confirmed that caspase-8 inhibition leads to this form of cell death [4].
Kostanyan, "PEDF--a noninhibitory serpin with neurotrophic activity," Acta Naturae, vol.
Serpin A1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the serpin super family of the serine protease inhibitors [12].
Alpha-1-antichymotrypsin (ACT), also called SERPINA3 [1], is a member of the serine protease inhibitor (serpin) family of acute phase proteins.
uPA is tightly controlled by the specific serpin inhibitor PAI-1, which is also upregulated in cancer.