One of the proposed pathways in epilepsy development is the serotoninergic
system, since 5-HT contributes to the neurodevelopment, functionality, and plasticity of the brain as it was stated before.
However, as exercise cessation approaches, the dopaminergic activity returns to basal values but the serotoninergic
activity remains high (15,27,65,72).
Aripiprazol, an atypical antipsychotic drug, acts as a partial agonist of the D2 dopaminergic and 5-HT1A serotoninergic
Data Sources: Papers in English published in PubMed, Cochrane, and Ovid Nursing databases between January 1988 and November 2016 were searched using the following keywords: PD, nondopaminergic therapy, adenosine, glutamatergic, adrenergic, serotoninergic
, histaminic, and iron chelator.
The mechanisms of paracetamol action have not yet been fully understood and may involve inhibition of central cyclooxygenase (COX-3) pathway in the central nervous system and interaction with the serotoninergic
Serotonin plays a major role in the expression of phototactic behavior in gammarids: Pomphorhynchus parasites increase brain serotoninergic
activity of gammarids (Tain et al., 2006, 2007), and experimental injection of serotonin in uninfected individuals mimics the behavioral changes induced by parasites (Perrot-Minnot et al., 2014).
(5) The serotoninergic
system, and the 5-hydroxytryptamine (5-HT) as the key neurotransmitter, has an antinociceptive role in the dorsal horn of the descending tract of the spinal cord.
deregulation could explain the development of anti-social behaviors in adults who experienced early-life stress (De Bellis et al., 2013).
Acute treatment targets the serotoninergic
system (such as triptans), the inflammatory reaction (nonsteroidal anti-inflammatory drugs), and calcitonin gene related protein (CGRP) receptors .
Classically, hallucinogenic agents were subdivided into those affecting the cholinergic system and those involving the aminergic system, herein dopaminergic and serotoninergic
agents being included .
neurons might mediate this action since leptin deficiency impacts on bone turnover; thus, metabolism can be overturned by obstructing serotonin secretion in the brainstem [5, 7, 27, 73].
For positive controls brain sections including the Raphe nucleus (rich in serotoninergic
neurons and recommended by manufacturer) were used; adrenal tissue was used as negative control (Figure 1).