serotonin transporter


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serotonin transporter (SERT),

a protein, found for example in the terminal of a presynaptic neuron, which decreases the concentration of serotonin near the synapse by effecting its reuptake into the presynaptic neuron.
See also: presynaptic.
References in periodicals archive ?
(2009), there was no correlation between genetic variations of serotonin transporter and response to citalopram (119).
Hamblin, "Chronic fluoxetine reduces serotonin transporter mRNA and 5-[HT.sub.1B] mRNA in a sequential manner in the rat dorsal raphe nucleus," Neuropsychopharmacology, vol.
Perez-Nevot et al., "Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy," Fertility and Sterility, vol.
Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample.
Thus, it is possible to suggest that the serotonin transporter gene's involvement in the development of depression is mediated by its influence on the function of the limbic system.
Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis.
Plasma serotonin levels and the platelet serotonin transporter. J Neurochem 2007;102:206-15.
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
Polymorphism of the serotonin transporter gene and pulmonary hypertension in chronic obstructive pulmonary disease.
The following six polymorphisms were included in the study: (1) the 44 bp insertion/deletion polymorphism in the promoter region (5-HTTLPR) of serotonin transporter gene (SLC6A4) (rs4795541), (2) the 5-HT1A receptor gene (HTR1A) C-1019G polymorphism (rs6295), (3) the 5-HT2A receptor gene (HTR2A) T102C polymorphism (rs6313), (4) HTR2A G-1438A polymorphism (rs6311), (5) the 5-HT2C receptor gene (HTR2C) cys23ser polymorphism (rs6318), and (6) the tryptophan hydroxylase-1 gene (TPH1) A218C polymorphism (rs1800532).

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