serotonin syndrome


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serotonin syndrome

an aggregation of symptoms resulting from elevated levels of serotonin, usually due to ingestion of two or more drugs (for example, MAOIs, SSRIs) that interfere with serotonin metabolism at different points. Symptoms occur on a spectrum and may include agitation, confusion, diaphoresis, diarrhea, fever, shivering, tremor, myoclonus, rigidity, trismus, opisthonus, seizures, drowsiness, hallucinations, and coma. Autonomic signs include abdominal pain, diarrhea, flushing, hypertension, mydriasis, salivation, tachycardia, and tachypnea. Hyperthermia is common. More advanced cases may include patients suffering DIC, rhabdomyolysis, renal failure, respiratory failure, and ARDS.

serotonin syndrome

an aggregation of symptoms resulting from elevated levels of serotonin, usually due to ingestion of two or more drugs (for example, MAOIs, SSRIs) that interfere with serotonin metabolism at different points. Symptoms occur on a spectrum and may include agitation, confusion, diaphoresis, diarrhea, fever, shivering, tremor, myoclonus, rigidity, trismus, opisthonus, seizures, drowsiness, hallucinations, and coma. Autonomic signs include abdominal pain, diarrhea, flushing, hypertension, mydriasis, salivation, tachycardia, and tachypnea. Hyperthermia is common. More advanced cases may include patients suffering DIC, rhabdomyolysis, renal failure, respiratory failure, and ARDS.

serotonin syndrome

Psychiatry A potentially life threatening condition caused by combined therapy with MAOIs and selective serotonin reuptake inhibitor–SSRI, antidepressants–Prozac, Zoloft, Paxil, Luvox, Wellbutrin–bupropion, tryptophan or tricyclic antidepressants, which abruptly ↑ serotonin resulting in neuromuscular, autonomic, and behavioral changes due to ↑ CNS serotonin activity Clinical Confusion, diaphoresis, ataxia, excitement, hyperthermia, hyperreflexia, myoclonus, hypotension, tremor Complications DIC, rhabdomyolisis, cardiovascular compromise Management D/C offending drug, support vital functions, dantrolene–muscle relaxant, Periactin–cyproheptadine–antihistamine, serotonin antagonist. See MAOI, SSRI.

serotonin syndrome

A potentially dangerous reaction to drug administration or drug interactions that involve excessive serotonergic agonism. The effects range from mild to life-threatening and include AKATHISIA, tremor, altered mental states, agitation, clonus, muscular hypertonicity, hyperthermia and death. Many drugs have been found to be implicated and these are not limited to the selective serotonin re-uptake inhibitors.

Serotonin syndrome

A group of symptoms caused by severely elevated serotonin levels in the body.
References in periodicals archive ?
They found that ,tramadol, not only has common adverse drug reactions that occur after consuming all opioids, it also has serious side effects such as serotonin syndrome and increased seizure risks.A
Following his discharge, it was discovered he had serotonin syndrome - a rare condition which may have been brought on by the use of medicines that increase levels of serotonin in the brain.
His discharge notes said he had serotonin syndrome - a rare condition which may be brought on by the use of medicines that increase levels of serotonin in the brain.
Serotonin syndrome is a drug-induced syndrome caused by overstimulation of serotonin receptors.
Serotonin syndrome risk with triptans and antidepressants very low !-- -- The risk of serotonin syndrome developing in individuals who are taking both triptans for migraine and either an SSRI or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant is very low, according to analysis of electronic health record data of 47,968 patients prescribed triptans.
The authors suggested that tramadol could potentially lead to serotonin syndrome. They also speculated that it could increase the risk of postoperative delirium, cause fatal poisoning or respiratory depression if taken in conjunction with alcohol or other drugs, or increase the risk of hypoglycemia, hyponatremia, fractures, or falls.
He exhibited no other signs or symptoms of serotonin syndrome viz:- altered mentation, diarrhoea, nausea and or vomiting.
Mixing Spice with other drugs could "stimulate serotonin activity in the brain, which can lead to serotonin syndrome, causing high fever, rapid pulse, sweating, agitation, confusion, convulsions, organ failure, coma and even death".
- Serotonin syndrome has been reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs.
The study of 14 years' worth of data, published online in JAMA Neurology, identified only two confirmed cases of serotonin syndrome, representing an incidence rate of 0.6 cases per 10,000 person-years of exposure, and five probable cases.
Food and Drug Administration issued an advisory warning on the risk of serotonin syndrome with concomitant use of triptans and SSRI or SNRI antidepressants, Yulia Orlova, M.D., Ph.D., from Brigham and Women's Hospital in Boston, and colleagues used electronic health record data to examine the risk of serotonin syndrome.
Of note, tramadol, owing to its powerful blockade of serotonin reuptake, was reported to cause serotonin syndrome even in the absence of concomitant use of antidepressants [15, 16].

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