These studies demonstrate that benzo[a]pyrene induces alterations in the
serotonergic system throughout the brain.
It is important to recognize that various
serotonergic agents are involved in the CYP450 system.
The new study of
serotonergic function in hoarding disorder, taken together with earlier brain imaging studies of regional glucose metabolism and functional MRI studies conducted by Dr.
The evolution of the
serotonergic system and its role in depression and the antidepressant response.
Therefore, it is crucial for physicians to be aware of undesirable
serotonergic adverse effects of tramadol.
Additionally, the authors proposed that, based on the findings, methanolic extract of Asparagus racemosus probably attenuates anxiety behaviour through modulation of the amygdalar
serotonergic and norepinephrinergic systems.
Thus, to assess the possible contribution of the
serotonergic system, mice were pretreated with 100 mg/kg, ip, PCPA, an inhibitor of serotonin (5-HT) synthesis, or vehicle, once a day, for 4 consecutive days.
In the literature on the etiology of OAB, the importance of low
serotonergic function is particularly emphasized for urinary system physiology and OAB pathophysiology as well as for many psychiatric conditions such as depression and anxiety (24).
The amount of
serotonergic activity most likely to cause serotonin syndrome is unclear.
(49,56) Based on current evidence, saffron appears to have limited effect on the
serotonergic system.
In fact, depression and anxiety may increase the perception of acute and chronic pain.[7,8] The
serotonergic and noradrenergic neuronal pathways have been clearly implicated in the etiology of depression as well as in pain modulation in the central nervous system.
The proposed pathophysiological mechanism involves anticholinergic effects and a possible
serotonergic mechanism due to the presence of 5-HT receptors in human eyes and their concentration in the mammalian ciliary body and cornea.[1] The strong stimulation of
serotonergic transmission could also account for the increase in IOP, as has been reported with other SSRIs.[1],[5] When stimulated by agonists, 5-HT receptors are responsible for relaxation of the sphincter muscle of the pupil and subsequent mydriasis.
