In March 2019, after 24 doses of intravenous belimumab and 1 dose of subcutaneous belimumab, the patient remains stable with no relapses of serositis
symptoms during the follow-up period.
(24) Further workup in this case revealed findings consistent with definite and active AIH, which would explain most of her signs and symptoms; however, in the end, the patient was diagnosed with AIH and SLE overlap (homogeneous ANA at 1:1,280, leucopenia, serositis
as per pleural effusion, and hypocomplementemia added to +anti-chromatin), as only the concurrent diagnoses could explain the entire scope of the clinical presentation seen in this case.
Among all connective tissue diseases, SLE is the second most common disease after systemic sclerosis in with PAH is common and affect disease prognosis.11 The prevalence of PH in SLE was 2.8-23.3%.9 A comparative study was conducted in which various pulmonary manifestations in SLE patients have been studied and pulmonary hypertension was found to be one of the important complication in such patients.12 In another meta-analysis of various studies, it was found that PAH was found in 8% of SLE patients.13 Various predictors of PAH are compared which are found directly with PAH, such as nephritis, serositis
(pleural and pericardial effusion), raynaud phenomenon and rheumatoid factor).
Japanese variant of multicentric Castleman's disease associated with serositis
and thrombocytopenia - A report of two cases: Is TAFRO syndrome (Castleman-Kojima disease) a distinct clinicopathological entity?
In 1987, Sir George Alfred still described this condition as it presents with systemic features like fever in 80%, salmon-pink rash affecting the trunk usually evanescent in 60%, lymphadenopathy in 32%, hepatosplenomegaly in 50%, serositis
in 10% and arthritis in 60%, rarely seizures, cholecystitis and uveitis.
Clinical data included fever, hepatomegaly, splenomegaly, hemorrhagic manifestations, lymphadenopathy, active arthritis, central nervous system (CNS) involvement and serositis
. Extensive laboratory workup was performed on all patients (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complete blood count, aspartate aminotransferase (AST), alanine aminotransferase, fibrinogen, D-dimer levels, ferritin, triglycerides, and immunologic parameters including anti-nuclear antibodies by indirect immunofluorescence and rheumatoid factor).
Familial mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease characterized by recurrent fever, serositis
, and erysipelas-like erythema.
In patients of active lupus nephritis in class III and IV, the symptoms of active SLE like fever, fatigue, serositis
, rash, arthritis or the feature of CNS involvement are more common.5 Some patients of lupus nephritis may be totally asymptomatic, seen in the class II and V of lupus nephritis.6
Systemic features, including fever, rash, serositis
, and hepatosplenomegaly, predominate in this group.
Familial Mediterranean fever (FMF) is an autosomal recessive, inflammatory disease, which is manifested by recurrent episodes of serositis
. In Turkey, the prevalence of FMF is generally known to be 1/1000 (1).
An increase in rate and depth of respirations and use of accessory muscles to breathe may indicate pleural serositis
(Hodkinson & Makda, 2015).
About 13 patients (17.1%) had alopecia and 15 patients (19.7%) had serositis
. Forty two patients (55.3%) had nephritis, 20 patients (26.3%) had lupus cerebritis, 57 patients (75%) had hematological involvement, 9 patients (11.83%) had pulmonary involvement, 8 patients (10.5%) had rheumatoid arthritis (RA) factor positive and 7 patients (9.2%) had overlap syndrome.