Delayed seroreversion at >18 months of age in HIV-uninfected infants has been described in Malawi, Vietnam, Brazil and the USA.
Whereas there are anecdotal observations of delayed seroreversion in uninfected infants >18 months of age from South Africa (SA), to the best of my knowledge there are no local published data regarding time to loss of antibodies using rapid tests in infants exposed to World Health Organization Option B/B+.
Moreover, late seroconversion, persistent seronegativity, and seroreversion
of IgG against HEV have been reported for severely immunocompromized patients, including some infected with HIV (3-5), which brings up the question as to whether prevalence of IgG against HEV is underestimated among severely immunocompromised persons infected with HIV.
INFLUENCE OF HIV ON THE COURSE OF HEPATITIS B VIRUS INFECTION * Higher rates of chronicity after acute HBV infection * Decreased rates of spontaneous HBsAg and HBeAg seroconversion * Increased rates of HBV DNA replication * More severe liver disease, with increased rates of cirrhosis and hepatocellular carcinoma * Increased rates of liver-related mortality * Increased rates of occult HBV infection * Increased rate of reactivation and seroreversion
with decreasing CD4 counts * Increase risk of HBV flare after starting HAART due to HBV-immune reconstitution inflammatory syndrome (HBV-IRIS) TABLE II.
This process, called seroreversion, usually occurs only in the last stages of the disease, when the immune system becomes too enfeebled to mount any antibody response to the virus.
blood supply as a result of seroreversion is extremely small because loss of HIV antibodies in the early stages of infection is so rare, the report's authors say.
Low seroprevalence rates of Ebola virus or Marburg virus found in surveys of patients in outbreak areas have been attributed to seroreversion
Indeterminate RIBA test results can indicate seroconversion or seroreversion
or, occasionally, a chronic infection when RNA HCV is detected in plasma (9,10).
However, triple reassortant SIV was not documented in swine in Canada until 2005 (8), which makes it unlikely that human cases occurred before that year and that seroreversion
had occurred in any of the persons in the current serosurvey.
was defined as a seropositive bird whose antibody titer decreased below the cut-off value of 20 at recapture.
was defined as a qualitative change from positive to negative, accompanied by [greater than or equal to] 2-fold decrease in H.
A total of 16 seroreversions
, compared with 70 seroconversions, occurred among persons in most age cohorts, mean age 48 years.