serine protease inhibitors

ser·ine pro·te·ase in·hib·i·tors

a class of highly polymorphic inhibitors of trypsin, elastase, and certain other proteases synthesized by hepatocytes and macrophages
See also: α1-antitrypsin.
Synonym(s): serpins
References in periodicals archive ?
5] Among other known serine protease inhibitors (SERPINs), the enhanced stability of PAI-1 might play a role in the development of autoimmune disease and the pathophysiology of vitiligo.
Differential expression of serine protease inhibitors 1 and 2 in Crassostrea corteziensis and C.
The presence of intestinal serine proteases in Oemona hirta Fabricius (Cerambycidae), also was supported by proteolytic assays using a general substrate and specific chemical inhibitors, which showed that only serine protease inhibitors had effect on total proteolytic activity; the predominant endopeptidase activity was attributed to trypsin and chymotrypsin-like proteases while, exopeptidase was related to leucine aminopeptidase.
Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.
This mixture of protease inhibitors contains the serine protease inhibitors AEBSF (1 mmol [l.
These include PPAR and liver X receptor activators (which are highly anti-inflammatory and improve barrier function), serine protease inhibitors (which may prevent stratum corneum damage and, ultimately, clinical expression of AD), and protease-activated receptor-2 inhibitors (to inhibit itching and inflammation).
Most of the serine protease inhibitors inhibit more than one type of serine protease, [13].
The serine protease inhibitors have been reported from various plant families with varying inhibition efficacy.
A dimeric 70-kDa chymotrypsin inhibitor with substantial N-terminal sequence homology to serine protease inhibitors was isolated from Acacia confusa seeds.
In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms.
Treatment benefit is accomplished by restoring the proper balance of key natural serine protease inhibitors, known as inter-alpha inhibitor proteins (IaIp).
The hK6 monoclonal antibody was used as the capture antibody; the rabbit polyclonal hK6 detection antibody was replaced with rabbit antibodies against each of six common serine protease inhibitors ([[alpha].

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