serine protease inhibitors

ser·ine pro·te·ase in·hib·i·tors

a class of highly polymorphic inhibitors of trypsin, elastase, and certain other proteases synthesized by hepatocytes and macrophages
See also: α1-antitrypsin.
Synonym(s): serpins
References in periodicals archive ?
Some studies have identified a serine-type protease inhibitor related to palmitoyltransferase that has an effect on melanogenesis.[5] Among other known serine protease inhibitors (SERPINs), the enhanced stability of PAI-1 might play a role in the development of autoimmune disease and the pathophysiology of vitiligo.
Differential expression of serine protease inhibitors 1 and 2 in Crassostrea corteziensis and C.
Serpin peptidase inhibitor clade E member 2 (SERPINE2/protease nexin-1) and secretory leukocyte protease inhibitor (SLPI) are secreted serine protease inhibitors which are overexpressed in a number of cancers and involved in tumor formation [5-7].
The presence of intestinal serine proteases in Oemona hirta Fabricius (Cerambycidae), also was supported by proteolytic assays using a general substrate and specific chemical inhibitors, which showed that only serine protease inhibitors had effect on total proteolytic activity; the predominant endopeptidase activity was attributed to trypsin and chymotrypsin-like proteases while, exopeptidase was related to leucine aminopeptidase.
Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.
This mixture of protease inhibitors contains the serine protease inhibitors AEBSF (1 mmol [l.sup.-1]) and aprotinin (0.8 mmol [l.sup.-1]); the amino-peptidase inhibitor bestatin (50 [micro] mol [l.sup.-1]); the cysteine protease inhibitor E-64 (15 [micro] mmol [l.sup.-1]); the broad-spectrum protease inhibitor leupeptin (20 [micro] mmol [l.sup.-1]); and the aspartyl protease inhibitor pepstatin A (10 [micro] mmol [l.sup.-1]).
Therefore, we investigated the potential therapeutic effects of the potent serine protease inhibitors FUT, FOY, and UTI on allergic airway inflammation and airway remodeling in a Der p-challenged murine model of chronic asthma.
These include PPAR and liver X receptor activators (which are highly anti-inflammatory and improve barrier function), serine protease inhibitors (which may prevent stratum corneum damage and, ultimately, clinical expression of AD), and protease-activated receptor-2 inhibitors (to inhibit itching and inflammation).
Te cell culture system may fail adequately to model the homeostatic environment of the brain, which is endowed not only with serine proteases and their zymogens but also naturally occurring serine protease inhibitors (serpins) [52, 53].
Most of the serine protease inhibitors inhibit more than one type of serine protease, [13].
Serine protease inhibitors are the best-known and most characterized inhibitors (Laskowski and Qasim, 2000).
A dimeric 70-kDa chymotrypsin inhibitor with substantial N-terminal sequence homology to serine protease inhibitors was isolated from Acacia confusa seeds.

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