The large family of serine hydrolases
are largely underexplored as drug targets.
The contract centres around Abide's technologies to selectively aim serine hydrolases
, "one of the largest enzyme families involved in regulating human physiology.
The researchers have used a set of compounds, recently synthesized by Cravatt's laboratory, that tend to inhibit serine hydrolases
Metabolism of profenofos enantiomers yields a mixture of toxicants that includes direct-acting and cytochrome P450 (CYP450)-activated inhibitors of acetylcholinesterase (AChE) and other serine hydrolases
(Glickman et al.
Specific examples will focus on serine hydrolases
and kinases with applications to drug discovery and development.
ABX-1431 was discovered with Abide's proprietary technology platform, which finds new small molecule drug candidates that target serine hydrolases
, a large class of enzymes with important regulatory roles in human physiology and disease.
There are more than 200 serine hydrolases
in human cells, but for most we've lacked chemical inhibitors of their activity," said team leader Benjamin F.
Therefore, the molecular events that define esterase OP inhibition (including reactivation and aging; Figure 2) are likely to be similar to serine hydrolases
, serine proteases, and other related proteins.
4, 2014 /PRNewswire/ -- Abide Therapeutics announced today that the Company has entered into a collaborative agreement with the University of Oxford and the Oxford University Hospitals NHS Trust to explore the therapeutic potential of serine hydrolases
, one of the largest enzyme classes with validated but under explored class of drug targets.
They screened a group of enzymes known as serine hydrolases
by measuring the activity levels of these enzymes in normal prostate epithelial cells and in three standard prostate cancer cell lines.
Abide has pioneered innovative technologies to selectively target serine hydrolases
, one of the largest enzyme families involved in regulating human physiology.
This collaboration with Abide illustrates our ongoing commitment to enable potentially disruptive technologies in the hands of talented drug hunters, here deployed in unique and powerful approach to target a validated but largely underexplored class of serine hydrolases
," said Thomas Daniel, M.