Mast cells are implicated in a number of inflammatory diseases through releasing of inflammatory mediators, serglycin
and other proteoglycans, and proteases .
The mRNAs included control housekeeping genes [actin, beta (ACTB)  and beta-2-microglobulin (B2M)] and myeloid [defensin, alpha 3, neutrophil-specific (DEFA3) and serglycin (SRGN)], erythroid [hemoglobin, beta (HBB) and uroporphyrinogen decarboxylase (UROD)], and megakaryocyte [integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) and integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3)] lineage-specific genes.
 Human genes: ACTB, actin, beta; B2M, beta-2-microglubulin; DEFA3, defensin, alpha 3, neutrophil-specific; SRGN, serglycin; HBB, hemoglobin, beta; UROD, uroporphyrinogen decarboxylase; ITGA2B, integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); ITGB3, integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); CD34, CD34 molecule; CD3E, CD3e molecule, epsilon (CD3-TCR complex); CD4, CD4 molecule; CD8A, CD8a molecule; CD19, CD19 molecule.
The genes which displayed decreased expression in hTERT-OA 13A FLSs included fibroblast growth factor 9 (FGF9: -29.84-fold), prostaglandin E receptor 4 (PTGER4: 10.03-fold), ANKH (-5.26-fold), pleiotrophin (PTN: -4.7-fold), parathyroid hormone-like hormone (PTHLH: -3.6-fold), and serglycin (SRGN: -1.9-fold).
Borset et al., "Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro" Journal ofBiological Chemistry, vol.
(1) Prestored cytoplasmic granules: (a) biogenic amines (e.g., histamine), (b) serglycin
proteoglycans (e.g., heparin and chondroitin sulphate), (c) serine proteases (tryptases, chymases, and carboxypeptidases), (d) some cytokines (e.g., TNF-[alpha] and VEGFA).
Working together with physicians and scientists at Sun Yat-sen University Cancer Center in China, VARI researchers found that the protein serglycin is a marker of metastasis for NPC.
Higher levels of serglycin correlated with an unfavourable prognosis and the increased likelihood that cancer would spread to other parts of the body.
Additionally, when researchers blocked the secretion of serglycin, it reduced the cells capacity to invade and metastasise, which could mean it may have potential as a therapeutic target to stop the spread of NPC.
"Serglycin is clearly important to metastasis in NPC, but there are other factors as well," Chao-Nan Qian, M.D.
MC-granules contain biogenic amines (histamine and, only in rodents, serotonin), serglycin
proteoglycans (heparin and chondroitin sulphate), serine proteases (tryptases, chymases, and carboxypeptidases), cytokines (such as TNF-[alpha]), and growth factors (such as vascular endothelial growth factor A (VEGFA)) .