sequence hypothesis


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se·quence hy·poth·e·sis

that the amino acid sequence of a protein is determined by a particular sequence of nucleotides (the cistron) in the DNA of the organism producing the protein.
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Crick later developed this idea with his famous "sequence hypothesis," according to which the nucleotide bases in DNA function like letters in a written language or symbols in a computer code.
Crick's "sequence hypothesis" neatly links the gene to the protein: the sequence of the nucleotides in a gene "is a simple code for the amino acid sequence of a particular protein." This is shorthand for a series of well-documented molecular processes that transcribe the gene's DNA nucleotide sequence into a complementary sequence of ribonucleic acid (RNA) nucleotides that, in turn, delivers the gene's code to the site of protein formation, where it determines the sequential order in which the different amino acids are linked to form the protein.
According to Crick's sequence hypothesis, the gene's nucleotide sequence (i.e., its "genetic information") is transmitted, altered in form but not in content, through RNA intermediaries, to the distinctive amino acid sequence of a particular protein.