2-Sep

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2-Sep

A gene on chromosome 2q37 that encodes septin 2, a member of the septin family of GTPases, which is a filament-forming cytoskeletal GTPase required for normal organisation of the actin cytoskeleton.
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In case of spots which displayed reduced expression levels, structural proteins like Septin-2, cofilin-1 and macrophage capping protein; proteins involved in cellular processes like Annexin 1, Annexin 4, Annexin 5 and proteins involved in metabolism like phosphoglycerate mutase, triosephosphate isomerase, peptidyl-prolyl cis-trans isomerase were identified (Figure 5; Table 2).
Some of the down regulated proteins identified in our proteomic analysis like LIM protein, annexin proteins, cofilin-1, Rho GDP-dissocaiation inhibitor 1 (Rho GDI) and septin-2 are already proved to be involved in myogeneis.