9-Sep

(redirected from septin 9)

9-Sep

A gene on chromosome 17q25 that encodes septin 9, a member of the septin family of nucleotide-binding proteins, which are required for cytokinesis, organisation of submembranous structures, neuronal polarity and vesicle trafficking. SEPT9 is a candidate for ovarian tumour suppressor gene.

Molecular pathology
SEPT9 mutations cause hereditary neuralgic amyotrophy (neuritis with brachial predilection). A translocation between SEPT9 and MLL on chromosome 11 results in acute myelomonocytic leukaemia.
References in periodicals archive ?
2008) Sensitive detection of colorectal cancer in peripheral blood by septin 9 DNA methylation assay.
2011) Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer.
For example, detection of septin 9 (SEPT9) gene hypermethylation in the blood has been used in colorectal carcinoma screening whereas detection of glutathione S-transferase pi (GSTPi) gene hypermethylation in urine has been utilized as a prostate cancer biomarker [10-12].
The program includes four 25-minute presentations given by speakers at the Institute's May 2009 Conference: Non-coding RNAs as Biomarkers in Human Cancers; From Discovery to the Clinic--The Novel DNA Methylation Biomarker, Septin 9, for the Detection of Colorectal Cancer in Blood; Cancer Biomarker Discovery in the Context of Individualized Medicine; and Metabolomics-derived Biochemical Markers of Prostate Cancer Aggressiveness.
With the data generated in the PRESEPT study, Epigenomics intends to demonstrate that colorectal cancer early detection with a blood test based on Septin 9 will meet the requirements of current U.
For each subject, blood samples are collected prior to bowel prep for colonoscopy and analyzed for methylated Septin 9 DNA by Epigenomics' partner Quest Diagnostics.
In this issue of Clinical Chemistry, Potter and colleagues describe a blood-based assay to detect ccfDNA methylated septin 9 (mSEPT9) and its ability to detect colon cancer (6).
Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island.