4-Sep

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4-Sep

A gene on chromosome 17q22 that encodes septin 4, a member of the septin family of nucleotide-binding proteins, which regulate cytoskeletal organisation. SEPT4 is highly expressed in brain and heart; its disruption alters cytokinesis.
References in periodicals archive ?
Papapetropoulos, "Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects," Movement Disorders, vol.
The Rockefeller University laboratory of Hermann Steller created mice that lack the gene septin 4. This gene is thought to be involved in apoptosis, the normal process that eliminates cells that are damaged, unwanted, or no longer needed.
Microscopic examination revealed that these sperm are missing the annulus, suggesting that this structure may be made of septin 4 protein, the production of which is controlled by the septin 4 gene.