sepsis


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Sepsis

 

Definition

Sepsis refers to a bacterial infection in the bloodstream or body tissues. This is a very broad term covering the presence of many types of microscopic disease-causing organisms.

Description

Sepsis is also called bacteremia. Closely related terms include septicemia and septic syndrome. In the general population, the incidence of sepsis is two people in 10,000. The number of deaths from sepsis each year has almost doubled in the United States since 1980 because more patients are developing the condition. There are three major factors responsible for this increase: a rise in the number of organ transplants and other surgical procedures that require suppressing the patient's immune system; the greater number of elderly people in the population; and the overuse of antibiotics to treat infectious illnesses, resulting in the development of drug-resistant bacteria.

Causes and symptoms

Sepsis can originate anywhere bacteria can gain entry to the body; common sites include the genitourinary tract, the liver and its bile ducts, the gastrointestinal tract, and the lungs. Broken or ulcerated skin can also provide access to bacteria commonly present in the environment. Invasive medical procedures, including dental work, can introduce bacteria or permit them to accumulate in the body. Entry points and equipment left in place for any length of time present a particular risk. Heart valve replacement, catheters, ostomy sites, intravenous (IV) or arterial lines, surgical wounds, or surgical drains are examples. IV drug users are at high risk as well.
People with inefficient immune systems, HIV infection, spinal cord injuries, or blood disorders are at particular risk for sepsis and have a higher death rate (up to 60%); in people who have no underlying chronic disease, the death rate is far lower (about 5%). The growing problem of antibiotic resistance has increased the incidence of sepsis, partly because ordinary preventive measures (such as prophylactic antibiotics) are less effective.
Cancer patients are at an increased risk of developing sepsis because chemotherapy and other forms of treatment for cancer weaken their immune systems.
The most common symptom of sepsis is fever, often accompanied by chills or shaking, or other flu-like symptoms. A history of any recent invasive procedure or dental work should raise the suspicion of sepsis and medical help should be sought.

Diagnosis

The presence of sepsis is indicated by blood tests showing particularly high or low white blood cell counts. The causative agent is determined by blood culture.
In some cases the doctor may order imaging studies to rule out pneumonia, or to determine whether the sepsis has developed from a ruptured appendix or other leakage from the digestive tract into the abdomen.

Treatment

Identifying the specific causative agent ultimately determines how sepsis is treated. However, time is of the essence, so a broad-spectrum antibiotic or multiple antibiotics will be administered until blood cultures reveal the culprit and treatment can be made specific to the organism. Intravenous antibiotic therapy is usually necessary and is administered in the hospital. The patient's chances of survival are increased by rapid admission to an intensive care unit followed by aggressive treatment with antibiotics.

Key terms

Bacteremia — The medical term for sepsis.
Prophylactic — Referring to medications or other treatments given to prevent disease.

Resources

Books

Beers, Mark H., MD, and Robert Berkow, MD., editors. "Bacteremia and Septic Shock." Section 13, Chapter 156 In The Merck Manual of Diagnosis and Therapy. Whitehouse Station, NJ: Merck Research Laboratories, 2004.

Periodicals

Cunha, Burke A., MD. "Sepsis, Bacterial." eMedicine September 29, 2004. http://www.emedicine.com/med/topic3163.htm.
Koranyi, K. I., and M. A. Ranalli. "Mycobacterium aurum Bacteremia in an Immunocompromised Child." Pediatric Infectious Diseases Journal 22 (December 2003): 1108-1109.
Larche, J., E. Azoulay, F. Fieux, et al. "Improved Survival of Critically Ill Cancer Patients with Septic Shock." Intensive Care Medicine 29 (October 2003): 1688-1695.
Paphitou, N. I., and K. V. Rolston. "Catheter-Related Bacteremia Caused by Agrobacterium radiobacter in a Cancer Patient: Case Report and Literature Review." Infection 31 (December 2003): 421-424.
Petrosillo, N., L. Pagani, G. Ippolito, et al. "Nosocomial Infections in HIV-Positive Patients: An Overview." Infection 31, Supplement 2 (December 2003): 28-34.
Wall, B. M., T. Mangold, K. M. Huch, et al. "Bacteremia in the Chronic Spinal Cord Injury Population: Risk Factors for Mortality." Journal of Spinal Cord Medicine 26 (Fall 2003): 248-253.

Organizations

American College of Epidemiology. 1500 Sunday Drive, Suite 102, Raleigh, NC 27607. (919) 861-5573. http://www.acepidemiology.org.
American Public Health Association (APHA). 800 I Street NW, Washington, DC 20001-3710. (202) 777-APHA. http://www.apha.org.
Centers for Disease Control and Prevention. 1600 Clifton Rd., NE, Atlanta, GA 30333. (800) 311-3435, (404) 639-3311. http://www.cdc.gov.

Other

"Supportive Care for Patients—Fever, Chills, and Sweats." National Cancer Institute Cancer Net 16 April 16, 2001. http://cancernet.nci.nih.gov/coping.html.

sepsis

 [sep´sis]
1. the presence in the blood or other tissues of pathogenic microorganisms or their toxins.
puerperal sepsis sepsis after childbirth, due to putrefactive matter absorbed from the birth canal; see also puerperal fever.

sep·sis

, pl.

sep·ses

(sep'sis, -sēz),
The presence of various pathogenic organisms, or their toxins, in the blood or tissues; septicemia is a common type of sepsis.
[G. sēpsis, putrefaction]

sepsis

(sĕp′sĭs)
n.
Systemic infection by pathogenic microorganisms, especially bacteria, that have invaded the bloodstream, usually from a local source. Sepsis is characterized by fever, increased number of white blood cells, increased heart rate, and other signs of widespread infection.

sepsis

Infectious disease Sepsis is defined by clinical parameters as 'SIRS–systemic inflammatory response syndrome plus a documented–ie, 'culture-positive' infection', and is part of a continuum of an inflammatory response to infection that evolves toward septic shock Clinical Tachypnea, tachycardia, hyperthermia, hypothermia Management Ibuprofen ↓ prostacyclin, thromboxane, ↓ tachycardia, fever, O2 consumption, lactic acidosis; NSAIDs do not prevent shock, ARDS, or improve survival. See Postanginal sepsis, Septic shock, Severe sepsis, SIRS.

sep·sis

, pl. sepses (sep'sis, -sēz)
The presence of various pus-forming and other pathogenic organisms, or their toxins, in the blood or tissues; septicemia is a common type of sepsis.
[G. sēpsis, putrefaction]

sepsis

The condition associated with the presence in the body tissues or the blood of micro-organisms that cause infection or of the toxins produced by such organisms. Sepsis varies in severity from a purely local problem to an overwhelming and fatal bacterial intoxication. Sepsis has been defined as the systemic inflammatory response to infection based on the clinical criteria of a temperature over 38 C, a heart rate of over 90 beats per minute, a respiratory rate of over 20 per minute and a white blood cell count increase of more than 12,000 or with more than 10 per cent immature neutrophil polymorphs. Severe sepsis is defined as sepsis associated with organ dysfunction. Severe sepsis has a mortality of up to 50 per cent.

sep·sis

, pl. sepses (sep'sis, -sēz)
Presence of various pathogenic organisms, or their toxins, in blood or tissues.
[G. sēpsis, putrefaction]

Patient discussion about sepsis

Q. What Is Sepsis? What does the term "sepsis" mean?

A. Sepsis is a very serious medical condition. It is characterized by an inflammatory state of the entire body, caused by an infection. The infection may be viral, bacterial or another, and sometimes is caused by specific bacterial toxins, in the blood or tissues.

More discussions about sepsis
References in periodicals archive ?
Out of 222 cases in the study group, 39 (17.57%) cases were culture proven sepsis. Of the 39-culture proven sepsis, Staphylococcus aureus 13(33.33%), Coagulase negative staphylococcus (CONS) 9 (23.07%), Methicillin resistant Staphylococcus aureus (MRSA) 8(20.51%), klebsiella 4 (10.26%), Candida 3 (7.69%), Pseudomonas 1(2.56%) and Acinetobacter 1 (2.56%).
Blood samples for the whole blood count, C-reactive protein (CRP), and culture were obtained from all neonates with suspected sepsis at admission and the hematologic parameters were evaluated according to the Manroe and Rodwell scoring systems.12,13 The neonates were categorized into 4 groups (highly probable sepsis; Group-I, probable sepsis; Group-II, possible sepsis; Group-III and no sepsis; Group-IV) according to the criteria defined by Gitto et al.14 The newborns in groups 1,2 and 3 were called as sepsis group and others with no signs of neonatal sepsis served as the control group, which consisted of infants diagnosed with transient tachypnea of the newborn (TTN) or neonatal hyperbilirubinemia.
Dr Damion Corrigan, from Strathclyde's department of biomedical engineering, said: "With sepsis, timing is key.
October 2018 Sepsis Decision Tool Usage, United States SIRS 59% QSOFA 24% SOFA 15% PEDIATRIC SIRS 2% Note: Table made from bar graph.
Conclusion: Sepsis has a high mortality rate in neonates admitted to our department.
Worldwide, one-third of people who develop sepsis die.
Researchers then used this data to create a "risk profile", which could be used to flag those patients at highest risk of dying from sepsis.
Reconocer que a pesar del numero inaceptable de muertes y discapacidades causadas por la sepsis, el conocimiento de la sepsis entre los proveedores de servicios de salud y el publico en general en los paises de LATAM es muy bajo.
Over the past six years, Thermo Fisher has worked with Sepsis Alliance, the Global Sepsis Alliance, and other advocates to raise awareness of the signs and symptoms of sepsis.
The global market for sepsis diagnostics is expected to reach USD 710 million by the end of the forecasted period and is expected to grow at a CAGR of 8%.